Technology Process of (R)-4-methyl-N-((4-phenyl-1,2,5-oxadiazol-3-yl)methyl)-2-(phenylsulfonamido)pentanamide
There total 10 articles about (R)-4-methyl-N-((4-phenyl-1,2,5-oxadiazol-3-yl)methyl)-2-(phenylsulfonamido)pentanamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-3-((4-methyl-2-(phenylsulfonamido)pentanamido)methyl)-4-phenyl-1,2,5-oxadiazole-2-oxide;
With
zinc;
In
methanol;
for 0.25h;
Inert atmosphere;
With
ammonium formate;
In
methanol;
at 60 ℃;
for 8h;
DOI:10.1021/jm201504s
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium azide / N,N-dimethyl-formamide / Heating; Inert atmosphere
2.1: triphenylphosphine / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
2.2: 1 h / Inert atmosphere
3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h / 0 °C / Inert atmosphere
3.2: 0 - 20 °C / Inert atmosphere
4.1: zinc / methanol / 0.25 h / Inert atmosphere
4.2: 8 h / 60 °C
With
dmap; sodium azide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; zinc;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
2.1: Staudinger reaction / 2.2: Staudinger reaction;
DOI:10.1021/jm201504s
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: pyridine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere
2.1: lithium hydroxide / tetrahydrofuran; methanol / 0 - 20 °C / Inert atmosphere
2.2: pH 2
3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h / 0 °C / Inert atmosphere
3.2: 0 - 20 °C / Inert atmosphere
4.1: zinc / methanol / 0.25 h / Inert atmosphere
4.2: 8 h / 60 °C
With
pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; zinc;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm201504s
