4'-BROMO-3-(4-CHLOROPHENYL)PROPIOPHENONE

Base Information

• Chemical Name: 4'-BROMO-3-(4-CHLOROPHENYL)PROPIOPHENONE
• CAS No.: 296271-45-9
• Molecular Formula: C₁₅H₁₂BrClO
• Molecular Weight: 323.617
• Mol file: 296271-45-9.mol

Synonyms:

Chemical Property of 4'-BROMO-3-(4-CHLOROPHENYL)PROPIOPHENONE

Chemical Property:

• Vapor Pressure: 1.1E-07mmHg at 25°C

Purity/Quality:

97% ^*data from raw suppliers

4'-Bromo-3-(4-chlorophenyl)propiophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-BROMO-3-(4-CHLOROPHENYL)PROPIOPHENONE

There total 2 articles about 4'-BROMO-3-(4-CHLOROPHENYL)PROPIOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

para-bromoacetophenone (99-90-1) + para-Chlorobenzyl alcohol (873-76-7) → 1-(4-bromophenyl)-3-(4-chlorophenyl)propan-1-one (296271-45-9)

Guidance literature:

With C₃₃H₄₀ClN₄Ru⁽¹⁺⁾*F₆P^(1-); potassium hydroxide; In toluene; at 120 ℃; Reagent/catalyst;

DOI:10.1002/cctc.202000254

Reference yield:

1-(4-bromophenyl)-3-(4-chlorophenyl)prop-2-en-1-one (6332-22-5) → 1-(4-bromophenyl)-3-(4-chlorophenyl)propan-1-one (296271-45-9)

Guidance literature:

With tris(triphenylphosphine)ruthenium(II) chloride; ethylene glycol; at 150 ℃; for 5h; regioselective reaction;

DOI:10.1021/op0000327

Reference yield:

1-(4-bromophenyl)-3-(4-chlorophenyl)propan-1-one (296271-45-9) → 2-[3-(4-bromophenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-5-(4-methoxybenzylidene)-1,3-thiazol-4(5H)-one (1382922-87-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 8 h / Reflux

2: sodium acetate; acetic acid / 15 h / Reflux

With sodium acetate; acetic acid; sodium hydroxide; In ethanol;

DOI:10.1007/s00044-012-0098-7

upstream raw materials:

1-(4-bromophenyl)-3-(4-chlorophenyl)prop-2-en-1-one

para-bromoacetophenone

para-Chlorobenzyl alcohol

Downstream raw materials:

5-benzylidene-2-[3-(4-bromophenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one

2-[3-(4-bromophenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-5-(4-chlorobenzylidene)-1,3-thiazol-4(5H)-one

2-[3-(4-bromophenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-5-(2-methoxybenzylidene)-1,3-thiazol-4(5H)-one

2-[3-(4-bromophenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-5-(4-methoxybenzylidene)-1,3-thiazol-4(5H)-one

Refernces

• 1、 Maji, Ankur,Singh, Anshu,Singh, Neetu,Ghosh, Kaushik. "Efficient Organoruthenium Catalysts for α-Alkylation of Ketones and Amide with Alcohols: Synthesis of Quinolines via Hydrogen Borrowing Strategy and their Mechanistic Studies". . p. 3108 - 3125. Retrieved 2020/05/18.
• 2、 Mukhopadhyay, Sudip,Yaghmur, Anan,Benichou, Axel,Sasson, Yoel. "Homogeneous RuCl2(PPh3)3-catalyzed regioselective liquid-phase transfer hydrogenation of carbon-carbon double bond in chlorobenzylidene ketones with ethylene glycol as hydrogen donor". . p. 571 - 574. Retrieved 2013/08/07.