N-(4-Chlorophenyl)-4-hydroxy-3-quinolinecarboxamide

Base Information

Chemical Name:N-(4-Chlorophenyl)-4-hydroxy-3-quinolinecarboxamide
CAS No.:77779-63-6
Molecular Formula:C₁₆H₁₁ClN₂O₂
Molecular Weight:298.729
Hs Code.:
DSSTox Substance ID:DTXSID901221345

Synonyms:SCHEMBL399686;N-(4-Chlorophenyl)-4-hydroxy-3-quinolinecarboxamide;DTXSID901221345;AKOS003078743;77779-63-6

Suppliers and Price of N-(4-Chlorophenyl)-4-hydroxy-3-quinolinecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-Chlorophenyl)-4-hydroxy-3-quinolinecarboxamide

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:298.0509053
Heavy Atom Count:21
Complexity:455

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(=O)C(=CN2)C(=O)NC3=CC=C(C=C3)Cl

Technology Process of N-(4-Chlorophenyl)-4-hydroxy-3-quinolinecarboxamide

There total 6 articles about N-(4-Chlorophenyl)-4-hydroxy-3-quinolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 52980-28-6
ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate

: 106-47-8
4-chloro-aniline

: 77779-63-6,873054-16-1
4-oxo-N'-(4-chlorophenyl)-1,4-dihydroquinoline-3-carboxamide

Guidance literature:: In diphenylether; at 210 ℃; for 1h;
DOI:10.3390/molecules19056651

Reference yield:

: C₁₆H₁₃ClN₂O₃

: 77779-63-6,873054-16-1
4-oxo-N'-(4-chlorophenyl)-1,4-dihydroquinoline-3-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1002/ejoc.201501048

Reference yield:

: 87-51-4
indole-3-acetic acid

: 77779-63-6,873054-16-1
4-oxo-N'-(4-chlorophenyl)-1,4-dihydroquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 16 h / 20 °C / Inert atmosphere

2.1: ozone / dichloromethane; methanol / 0.25 h / -78 °C / Inert atmosphere

2.2: 3 h / -78 - 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane; methanol / 18 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; ozone; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; acetonitrile;
DOI:10.1002/ejoc.201501048