2-(4-Bromomethyl-benzoyl)-cyclopentanecarboxylic acid {(S)-1-[(1R,2S)-2-(3-chloro-phenyl)-cyclohexylcarbamoyl]-3-methyl-butyl}-amide

Base Information

• Chemical Name: 2-(4-Bromomethyl-benzoyl)-cyclopentanecarboxylic acid {(S)-1-[(1R,2S)-2-(3-chloro-phenyl)-cyclohexylcarbamoyl]-3-methyl-butyl}-amide
• CAS No.: 911141-89-4
• Molecular Formula: C₃₂H₄₀BrClN₂O₃
• Molecular Weight: 616.038
• Mol file: 911141-89-4.mol

Synonyms:

Chemical Property of 2-(4-Bromomethyl-benzoyl)-cyclopentanecarboxylic acid {(S)-1-[(1R,2S)-2-(3-chloro-phenyl)-cyclohexylcarbamoyl]-3-methyl-butyl}-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-Bromomethyl-benzoyl)-cyclopentanecarboxylic acid {(S)-1-[(1R,2S)-2-(3-chloro-phenyl)-cyclohexylcarbamoyl]-3-methyl-butyl}-amide

There total 6 articles about 2-(4-Bromomethyl-benzoyl)-cyclopentanecarboxylic acid {(S)-1-[(1R,2S)-2-(3-chloro-phenyl)-cyclohexylcarbamoyl]-3-methyl-butyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,2S)-2-(3-Chloro-phenyl)-cyclohexylamine (911141-79-2) → 2-(4-Bromomethyl-benzoyl)-cyclopentanecarboxylic acid {(S)-1-[(1R,2S)-2-(3-chloro-phenyl)-cyclohexylcarbamoyl]-3-methyl-butyl}-amide (911141-89-4)

Guidance literature:

Multi-step reaction with 3 steps

1: EDC / CH₂Cl₂

2: HCl

3: EDC / CH₂Cl₂

With hydrogenchloride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;

DOI:10.1016/j.bmcl.2005.12.004

Reference yield:

1-chloro-3-((1S,2S)-2-nitrocyclohexyl)benzene → 2-(4-Bromomethyl-benzoyl)-cyclopentanecarboxylic acid {(S)-1-[(1R,2S)-2-(3-chloro-phenyl)-cyclohexylcarbamoyl]-3-methyl-butyl}-amide (911141-89-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 99 percent / NaHCO₃ / ethanol / 4 h

2: 100 percent / Zn; AcOH / methanol

3: EDC / CH₂Cl₂

4: HCl

5: EDC / CH₂Cl₂

With hydrogenchloride; sodium hydrogencarbonate; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; zinc; In methanol; ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2005.12.004

Reference yield:

1-chloro-3-((1S,2R)-2-nitrocyclohexyl)benzene (312611-42-0) → 2-(4-Bromomethyl-benzoyl)-cyclopentanecarboxylic acid {(S)-1-[(1R,2S)-2-(3-chloro-phenyl)-cyclohexylcarbamoyl]-3-methyl-butyl}-amide (911141-89-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / Zn; AcOH / methanol

2: EDC / CH₂Cl₂

3: HCl

4: EDC / CH₂Cl₂

With hydrogenchloride; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; zinc; In methanol; dichloromethane;

DOI:10.1016/j.bmcl.2005.12.004

upstream raw materials:

(S)-2-Amino-4-methyl-pentanoic acid [(1R,2S)-2-(3-chloro-phenyl)-cyclohexyl]-amide

(1R,2S)-2-(3-Chloro-phenyl)-cyclohexylamine

1-chloro-3-((1S,2R)-2-nitrocyclohexyl)benzene

trans-2-(4-methylbenzoyl)cyclopentane-1-carboxylic acid