5-Bromo-2-iodo-4-methyl-phenylamine

Base Information

• Chemical Name: 5-Bromo-2-iodo-4-methyl-phenylamine
• CAS No.: 1643156-27-7
• Molecular Formula: C₇H₇BrIN
• Molecular Weight: 311.948
• Mol file: 1643156-27-7.mol

Synonyms:

Chemical Property of 5-Bromo-2-iodo-4-methyl-phenylamine

Chemical Property:

• Boiling Point: 314.4±42.0 °C(Predicted)
• PKA: 1.90±0.10(Predicted)
• Density: 2.133±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

5-Bromo-2-iodo-4-methylphenylamine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Bromo-2-iodo-4-methyl-phenylamine

There total 1 articles about 5-Bromo-2-iodo-4-methyl-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

3-bromo-4-methylaniline (7745-91-7) → 5-bromo-2-iodo-4-methylaniline (1643156-27-7)

Guidance literature:

With N-iodo-succinimide; [bis(pyridine)iodine]⁺ tetrafluoroborate; In dichloromethane; at 20 ℃;

Reference yield: 83.0%

zinc(II) cyanide (557-21-1) + 5-bromo-2-iodo-4-methylaniline (1643156-27-7) → 2-amino-4-bromo-5-methylbenzonitrile

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 90 ℃; Inert atmosphere;

Reference yield:

5-bromo-2-iodo-4-methylaniline (1643156-27-7) + p-toluenesulfonyl chloride (98-59-9) → N-(5-bromo-2-iodo-4-methylphenyl)-4-methylbenzenesulfonamide

Guidance literature:

With pyridine; In acetonitrile; at 25 ℃; for 10h; Temperature; Solvent;

upstream raw materials:

3-bromo-4-methylaniline

Refernces

• 1、 Watterson, Scott H.,De Lucca, George V.,Shi, Qing,Langevine, Charles M.,Liu, Qingjie,Batt, Douglas G.,Beaudoin Bertrand, Myra,Gong, Hua,Dai, Jun,Yip, Shiuhang,Li, Peng,Sun, Dawn,Wu, Dauh-Rurng,Wang, Chunlei,Zhang, Yingru,Traeger, Sarah C.,Pattoli, Mark A.,Skala, Stacey,Cheng, Lihong,Obermeier, Mary T.,Vickery, Rodney,Discenza, Lorell N.,D'Arienzo, Celia J.,Zhang, Yifan,Heimrich, Elizabeth,Gillooly, Kathleen M.,Taylor, Tracy L.,Pulicicchio, Claudine,McIntyre, Kim W.,Galella, Michael A.,Tebben, Andy J.,Muckelbauer, Jodi K.,Chang, Chiehying,Rampulla, Richard,Mathur, Arvind,Salter-Cid, Luisa,Barrish, Joel C.,Carter, Percy H.,Fura, Aberra,Burke, James R.,Tino, Joseph A.. "Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers". . p. 9173 - 9200. Retrieved 2016/10/22.