Bromo-PEG2-acid

Base Information

• Chemical Name: Bromo-PEG2-acid
• CAS No.: 1807503-92-9
• Molecular Formula: C₇H₁₃BrO₄
• Molecular Weight: 241.082
• Hs Code.: 2918999090
• Mol file: 1807503-92-9.mol

Synonyms:

Chemical Property of Bromo-PEG2-acid

Chemical Property:

• Boiling Point: 347.2±27.0 °C(Predicted)
• PKA: 4.27±0.10(Predicted)
• Density: 1.464±0.06 g/cm3(Predicted)
• Storage Temp.: -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Bromo-PEG2-acid 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Bromo-PEG2-acid is a PEG linker containing a bromide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
• Uses: Bromo-PEG2-acid is a heterobifunctional, PEGylated crosslinker featuring a bromo group at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. Bromo-PEG2-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.

Technology Process of Bromo-PEG2-acid

There total 2 articles about Bromo-PEG2-acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 3-(2-(2-bromoethoxy)ethoxy)propanoate → 3-[2-(2-bromoethoxy)ethoxy]propanoic acid (1807503-92-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

2-methyl-2-propanyl 3-[2-(2-hydroxyethoxy)ethoxy]propanoate (133803-81-3,892154-71-1) → 3-[2-(2-bromoethoxy)ethoxy]propanoic acid (1807503-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 0 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

With carbon tetrabromide; triphenylphosphine; trifluoroacetic acid; In dichloromethane;

upstream raw materials:

2-methyl-2-propanyl 3-[2-(2-hydroxyethoxy)ethoxy]propanoate

Refernces

• 1、 -. "PCSK9 ANTAGONIST COMPOUNDS". . . Retrieved 2021/06/26.