Technology Process of C12H16O2S
There total 4 articles about C12H16O2S which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: dmap; diisopropyl-carbodiimide / dichloromethane / 12 h / 20 °C
2: 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methyl)thiourea / toluene / 72 h / 20 °C
3: lithium hydroxide monohydrate / tetrahydrofuran; water / 3 h / 20 °C
4: diethyl ether / 0.5 h / 20 °C
With
1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methyl)thiourea; dmap; lithium hydroxide monohydrate; diisopropyl-carbodiimide;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; toluene;
2: sulfa-Michael addition;
DOI:10.1021/ol202808n
- Guidance literature:
-
Multi-step reaction with 2 steps
1: lithium hydroxide monohydrate / tetrahydrofuran; water / 3 h / 20 °C
2: diethyl ether / 0.5 h / 20 °C
With
lithium hydroxide monohydrate;
In
tetrahydrofuran; diethyl ether; water;
DOI:10.1021/ol202808n
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methyl)thiourea / toluene / 72 h / 20 °C
2: lithium hydroxide monohydrate / tetrahydrofuran; water / 3 h / 20 °C
3: diethyl ether / 0.5 h / 20 °C
With
1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methyl)thiourea; lithium hydroxide monohydrate;
In
tetrahydrofuran; diethyl ether; water; toluene;
1: sulfa-Michael addition;
DOI:10.1021/ol202808n
