Methyl (2S)-2-methylbutanoate

Base Information

• Chemical Name: Methyl (2S)-2-methylbutanoate
• CAS No.: 10307-60-5
• Molecular Formula: C6H12O2
• Molecular Weight: 116.16
• Mol file: 10307-60-5.mol

Synonyms:Butanoicacid, 2-methyl-, methyl ester, (S)-;Butyric acid, 2-methyl-, methyl ester,(+)- (8CI);(+)-Methyl 2-methylbutanoate;(+)-Methyl 2-methylbutyrate;(+)-Methyl a-methylbutyrate;(S)-2-Methylbutanoic acid methyl ester;(S)-Methyl 2-methylbutanoate;Methyl(2S)-2-methylbutanoate;Methyl (S)-2-methylbutyrate;(S)-2-Methylbutanoic acid methyl ester; Methyl (2S)-2-methylbutanoate;

Chemical Property of Methyl (2S)-2-methylbutanoate

Chemical Property:

• Vapor Pressure: 21.6mmHg at 25°C
• Refractive Index: 1.395
• Boiling Point: 112.6 °C at 760 mmHg
• Flash Point: 19.4 °C
• PSA: 26.30000
• Density: 0.883 g/cm³
• LogP: 1.20550

Purity/Quality:

98%,99%, ^*data from raw suppliers

(2S)-2-Methyl-butanoicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl (2S)-2-methylbutanoate

There total 32 articles about Methyl (2S)-2-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + (S)-2-Methylbutyric acid (1730-91-2) → (S)-2-methylbutyric acid methyl ester (10307-60-5)

Guidance literature:

In diethyl ether; at 20 ℃; for 1h;

DOI:10.1002/(SICI)1099-0690(199909)1999:9<2167::AID-EJOC2167>3.0.CO;2-L

Reference yield: 75.0%

C12H16O2S (1346946-90-4) → (S)-2-methylbutyric acid methyl ester (10307-60-5)

Guidance literature:

With sodium phosphinate hydrate; In tetrahydrofuran; methanol; optical yield given as %ee; aq. acetate buffer;

DOI:10.1021/ol202808n

Reference yield:

methanol (67-56-1) + (S)-jalapinolic acid 11-O-α-L-rhamnopyranosyl-(1->3)-O-[2-O-trans-cinnamoyl-3-O-isobutanoyl-α-L-rhamnopyranosyl-(1->4)]-O-[2-O-(S)-2-methylbutyryl]-α-L-rhamnopyranosyl-(1->4)-O-α-L-rhamnopyranosyl-(1->2)-O-β-D-fucopyranoside 1,3'' ester (1020196-42-2) → (S)-2-methylbutyric acid methyl ester (10307-60-5) + Methyl isobutyrate (547-63-7,133320-07-7,67505-84-4) + Methyl cinnamate (103-26-4,1754-62-7)

Guidance literature:

(S)-jalapinolic acid 11-O-α-L-rhamnopyranosyl-(1->3)-O-[2-O-trans-cinnamoyl-3-O-isobutanoyl-α-L-rhamnopyranosyl-(1->4)]-O-[2-O-(S)-2-methylbutyryl]-α-L-rhamnopyranosyl-(1->4)-O-α-L-rhamnopyranosyl-(1->2)-O-β-D-fucopyranoside 1,3'' ester; With potassium hydroxide; at 90 ℃; for 2h; Reflux;

methanol; With sulfuric acid; In water;

DOI:10.1021/jf0733463

upstream raw materials:

diazomethane

(S)-2-Methylbutyric acid

methanol

((R)-1-Ethyl-prop-2-ynyl)-carbamic acid methyl ester

Downstream raw materials:

((S)-2-methyl-butyryl)-hydrazine

(S)-2,3-Dimethyl-2-pentanol

(R)-2,3-Dimethyl-2-pentanol

2,3-dimethylpent-2-ene