Technology Process of 3-{6-[2-fluoro-5-(trifluoromethyl)phenyl]-3-pyridinyl}-2,6-dimethyl-4H-pyran-4-one
There total 6 articles about 3-{6-[2-fluoro-5-(trifluoromethyl)phenyl]-3-pyridinyl}-2,6-dimethyl-4H-pyran-4-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate; triphenylphosphine;
In
ethanol; water; toluene;
at 95 ℃;
for 2.5h;
Inert atmosphere;
DOI:10.1021/acs.jmedchem.7b01256
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: iron; acetic acid / 2 h / Inert atmosphere; Reflux
2.1: polyphosphoric acid / water; phosphoric acid / 1.5 h / 95 °C / Inert atmosphere
3.1: water; hydrogenchloride / 48 h / 110 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 0.03 h / 20 °C
4.2: 1 h / 20 °C
5.1: bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine; sodium hydrogencarbonate / toluene; water; ethanol / 2.5 h / 95 °C / Inert atmosphere
With
hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; water; iron; sodium hydrogencarbonate; potassium carbonate; acetic acid; triphenylphosphine;
In
ethanol; phosphoric acid; water; N,N-dimethyl-formamide; toluene;
5.1: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.7b01256
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: polyphosphoric acid / water; phosphoric acid / 1.5 h / 95 °C / Inert atmosphere
2.1: water; hydrogenchloride / 48 h / 110 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 0.03 h / 20 °C
3.2: 1 h / 20 °C
4.1: bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine; sodium hydrogencarbonate / toluene; water; ethanol / 2.5 h / 95 °C / Inert atmosphere
With
hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; water; sodium hydrogencarbonate; potassium carbonate; triphenylphosphine;
In
ethanol; phosphoric acid; water; N,N-dimethyl-formamide; toluene;
4.1: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.7b01256