N-[N-(4-phenyl-3-chloro-2-oxo-azetidin-1-yl)acetamidyl]-5-nitroindazole

Base Information

• Chemical Name: N-[N-(4-phenyl-3-chloro-2-oxo-azetidin-1-yl)acetamidyl]-5-nitroindazole
• CAS No.: 1277174-71-6
• Molecular Formula: C₁₈H₁₄ClN₅O₄
• Molecular Weight: 399.793
• Mol file: 1277174-71-6.mol

Synonyms:

Chemical Property of N-[N-(4-phenyl-3-chloro-2-oxo-azetidin-1-yl)acetamidyl]-5-nitroindazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[N-(4-phenyl-3-chloro-2-oxo-azetidin-1-yl)acetamidyl]-5-nitroindazole

There total 4 articles about N-[N-(4-phenyl-3-chloro-2-oxo-azetidin-1-yl)acetamidyl]-5-nitroindazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N-(N-(benzylideneamino)acetamidyl)-5-nitroindazole (1245567-14-9) + chloroacetyl chloride (79-04-9) → N-[N-(4-phenyl-3-chloro-2-oxo-azetidin-1-yl)acetamidyl]-5-nitroindazole (1277174-71-6)

Guidance literature:

With triethylamine; for 0.05h; Microwave irradiation; Neat (no solvent);

Reference yield:

N-(ethyl ethanoate)-5-nitroindazole (126401-86-3) → N-[N-(4-phenyl-3-chloro-2-oxo-azetidin-1-yl)acetamidyl]-5-nitroindazole (1277174-71-6)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / 0.06 h / Microwave irradiation; Neat (no solvent)

2: 0.02 h / Microwave irradiation; Neat (no solvent)

3: triethylamine / 0.05 h / Microwave irradiation; Neat (no solvent)

With hydrazine hydrate; triethylamine;

Reference yield:

5-nitroindazole (5401-94-5) → N-[N-(4-phenyl-3-chloro-2-oxo-azetidin-1-yl)acetamidyl]-5-nitroindazole (1277174-71-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 0.03 h / Microwave irradiation; Neat (no solvent)

2: hydrazine hydrate / 0.06 h / Microwave irradiation; Neat (no solvent)

3: 0.02 h / Microwave irradiation; Neat (no solvent)

4: triethylamine / 0.05 h / Microwave irradiation; Neat (no solvent)

With hydrazine hydrate; triethylamine;

upstream raw materials:

2-(5-nitroindazol-1-yl)acetohydrazide

benzaldehyde

N-(N-(benzylideneamino)acetamidyl)-5-nitroindazole

chloroacetyl chloride