Benzoic acid (2S,3R,4S,5R,6S)-4-benzyloxy-6-(tert-butyl-dimethyl-silanyloxymethyl)-5-(4-oxo-pentanoyloxy)-2-phenylsulfanyl-tetrahydro-pyran-3-yl ester

Base Information

Chemical Name:Benzoic acid (2S,3R,4S,5R,6S)-4-benzyloxy-6-(tert-butyl-dimethyl-silanyloxymethyl)-5-(4-oxo-pentanoyloxy)-2-phenylsulfanyl-tetrahydro-pyran-3-yl ester
CAS No.:175978-42-4
Molecular Formula:C₃₇H₄₆O₈SSi
Molecular Weight:678.919
Hs Code.:

Benzoic acid (2S,3R,4S,5R,6S)-4-benzyloxy-6-(tert-butyl-dimethyl-silanyloxymethyl)-5-(4-oxo-pentanoyloxy)-2-phenylsulfanyl-tetrahydro-pyran-3-yl ester

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Chemical Property of Benzoic acid (2S,3R,4S,5R,6S)-4-benzyloxy-6-(tert-butyl-dimethyl-silanyloxymethyl)-5-(4-oxo-pentanoyloxy)-2-phenylsulfanyl-tetrahydro-pyran-3-yl ester

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Technology Process of Benzoic acid (2S,3R,4S,5R,6S)-4-benzyloxy-6-(tert-butyl-dimethyl-silanyloxymethyl)-5-(4-oxo-pentanoyloxy)-2-phenylsulfanyl-tetrahydro-pyran-3-yl ester

There total 6 articles about Benzoic acid (2S,3R,4S,5R,6S)-4-benzyloxy-6-(tert-butyl-dimethyl-silanyloxymethyl)-5-(4-oxo-pentanoyloxy)-2-phenylsulfanyl-tetrahydro-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 175978-42-4
Benzoic acid (2S,3R,4S,5R,6S)-4-benzyloxy-6-(tert-butyl-dimethyl-silanyloxymethyl)-5-(4-oxo-pentanoyloxy)-2-phenylsulfanyl-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N, DMAP / CH₂Cl₂ / Ambient temperature

2: Et₃N / CH₂Cl₂ / 1 h

With dmap; triethylamine; In dichloromethane;
DOI:10.1016/0008-6215(95)00346-0

Reference yield:

: 108-98-5
thiophenol

: 175978-42-4
Benzoic acid (2S,3R,4S,5R,6S)-4-benzyloxy-6-(tert-butyl-dimethyl-silanyloxymethyl)-5-(4-oxo-pentanoyloxy)-2-phenylsulfanyl-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 89 percent / BF₃*Et₂O / CH₂Cl₂ / 2 h / 25 °C

2: MeONa / methanol

3: TFA / 3 h / Ambient temperature

4: 96 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

5: 80percent aq. AcOH / 0.25 h / 100 °C

6: Et₃N, DMAP / CH₂Cl₂ / Ambient temperature

7: Et₃N / CH₂Cl₂ / 1 h

With dmap; boron trifluoride diethyl etherate; sodium methylate; acetic acid; triethylamine; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1016/0008-6215(95)00346-0

Reference yield:

: 175978-39-9
phenyl 3-O-benzyl-1-thio-α-L-idopyranoside

: 175978-42-4
Benzoic acid (2S,3R,4S,5R,6S)-4-benzyloxy-6-(tert-butyl-dimethyl-silanyloxymethyl)-5-(4-oxo-pentanoyloxy)-2-phenylsulfanyl-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: TFA / 3 h / Ambient temperature

2: 96 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

3: 80percent aq. AcOH / 0.25 h / 100 °C

4: Et₃N, DMAP / CH₂Cl₂ / Ambient temperature

5: Et₃N / CH₂Cl₂ / 1 h

With dmap; acetic acid; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/0008-6215(95)00346-0