Technology Process of N(2)-[3,6-diethyl-5(2,4-dichlorophenyl)pyrazin-2-yl]-N(1),N(1)-dimethylpropane-1,2-diamine
There total 3 articles about N(2)-[3,6-diethyl-5(2,4-dichlorophenyl)pyrazin-2-yl]-N(1),N(1)-dimethylpropane-1,2-diamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C
1.2: 4 h / 90 °C
2.1: tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine / toluene / 0.25 h / 20 °C / Inert atmosphere
2.2: 4 h / 80 °C / Inert atmosphere
With
tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane; toluene;
2.1: Buchwald coupling / 2.2: Buchwald coupling;
DOI:10.1021/jm200365y
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / water; toluene / 4 h / Inert atmosphere; Heating
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C
2.2: 4 h / 90 °C
3.1: tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine / toluene / 0.25 h / 20 °C / Inert atmosphere
3.2: 4 h / 80 °C / Inert atmosphere
With
tris-(dibenzylideneacetone)dipalladium(0); tetrakis(triphenylphosphine) palladium(0); tri-tert-butyl phosphine; potassium carbonate; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane; water; toluene;
1.1: Suzuki coupling / 3.1: Buchwald coupling / 3.2: Buchwald coupling;
DOI:10.1021/jm200365y
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / water; toluene / 4 h / Inert atmosphere; Heating
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C
2.2: 4 h / 90 °C
3.1: tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine / toluene / 0.25 h / 20 °C / Inert atmosphere
3.2: 4 h / 80 °C / Inert atmosphere
With
tris-(dibenzylideneacetone)dipalladium(0); tetrakis(triphenylphosphine) palladium(0); tri-tert-butyl phosphine; potassium carbonate; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane; water; toluene;
1.1: Suzuki coupling / 3.1: Buchwald coupling / 3.2: Buchwald coupling;
DOI:10.1021/jm200365y
