5-Hexynal, 6-phenyl-

Base Information

• Chemical Name: 5-Hexynal, 6-phenyl-
• CAS No.: 130602-09-4
• Molecular Formula: C12H12O
• Molecular Weight: 172.227
• Mol file: 130602-09-4.mol

Synonyms:

Chemical Property of 5-Hexynal, 6-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Hexynal, 6-phenyl-

There total 9 articles about 5-Hexynal, 6-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

6-phenylhex-5-yn-1-ol (69936-53-4) → 6-phenylhex-5-yn-1-al (130602-09-4)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 35 ℃; for 5h;

DOI:10.1021/ja037423w

Reference yield: 72.0%

Dess-Martin periodane (87413-09-0) + 6-phenylhex-5-yn-1-ol (69936-53-4) → 6-phenylhex-5-yn-1-al (130602-09-4)

Guidance literature:

In dichloromethane; at 20 ℃; for 3h; Inert atmosphere; Schlenk technique;

DOI:10.1021/ol5020027

Reference yield:

5-hexyl-1-ol (928-90-5) → 6-phenylhex-5-yn-1-al (130602-09-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / triethylamine; CuI / Pd(PPh₃)2Cl₂ / 12 h

2: 93 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -78 - 20 °C

With copper(l) iodide; oxalyl dichloride; dimethyl sulfoxide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; 2: Swern oxidation;

DOI:10.1021/jo0707939

upstream raw materials:

6-phenylhex-5-yn-1-ol

iodobenzene

5-hexyl-1-ol

phenylacetylene

Downstream raw materials:

(E)-2-(phenylmethylene)cyclopentanol

(Z)-2-Benzylidenecyclopentan-1-ol

diethyl (1-phenyl-1-hexyn-6-yl)malonate

1-(tert-butyldimethylsilanyloxy)-9-phenylnon-8-yn-4-ol