<3S^*,4α,5α>-3a,5,6,6a-tetrahydro-3-(2-hydroxy-2-phenylethyl)-4H-cyclopentisoxazole

Base Information

• Chemical Name: <3S^*,4α,5α>-3a,5,6,6a-tetrahydro-3-(2-hydroxy-2-phenylethyl)-4H-cyclopentisoxazole
• CAS No.: 133116-52-6
• Molecular Formula: C₁₄H₁₇NO₂
• Molecular Weight: 231.294

Synonyms:

Chemical Property of <3S^*,4α,5α>-3a,5,6,6a-tetrahydro-3-(2-hydroxy-2-phenylethyl)-4H-cyclopentisoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <3S^*,4α,5α>-3a,5,6,6a-tetrahydro-3-(2-hydroxy-2-phenylethyl)-4H-cyclopentisoxazole

There total 2 articles about <3S^*,4α,5α>-3a,5,6,6a-tetrahydro-3-(2-hydroxy-2-phenylethyl)-4H-cyclopentisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Methyl-4,5,6,6a-tetrahydro-3aH-cyclopentisoxazol (69423-36-5) + benzaldehyde (100-52-7) → <3R*,4α,5α>-3a,5,6,6a-tetrahydro-3-(2-hydroxy-2-phenylethyl)-4H-cyclopentisoxazole (133116-52-6,133163-87-8) + <3S*,4α,5α>-3a,5,6,6a-tetrahydro-3-(2-hydroxy-2-phenylethyl)-4H-cyclopentisoxazole (133116-52-6,133163-87-8)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given;

DOI:10.1016/S0040-4020(01)89051-7

Reference yield:

3-Methyl-4,5,6,6a-tetrahydro-3aH-cyclopentisoxazol (69423-36-5) + benzaldehyde (100-52-7) → <3R*,4α,5α>-3a,5,6,6a-tetrahydro-3-(2-hydroxy-2-phenylethyl)-4H-cyclopentisoxazole (133116-52-6,133163-87-8) + <3S*,4α,5α>-3a,5,6,6a-tetrahydro-3-(2-hydroxy-2-phenylethyl)-4H-cyclopentisoxazole (133116-52-6,133163-87-8)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given;

DOI:10.1016/S0040-4020(01)89051-7

Reference yield:

<3R*,4α,5α>-3a,5,6,6a-tetrahydro-3-(2-hydroxy-2-phenylethyl)-4H-cyclopentisoxazole (133116-52-6,133163-87-8) → <3S*,4α,5α>-3a,5,6,6a-tetrahydro-3-(1-methyl-2-phenylethyl)-4H-cyclopentisoxazole (107770-21-8,107869-81-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) LDEA, hexamethylphosphoric triamide / 1) THF, -78 deg C

3: Bu₃SnH, AIBN / benzene / 1 h / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene;

DOI:10.1016/S0040-4020(01)89051-7

upstream raw materials:

3-Methyl-4,5,6,6a-tetrahydro-3aH-cyclopentisoxazol

benzaldehyde

Downstream raw materials:

<3S^*,4α,5α>-3a,5,6,6a-tetrahydro-3-(anti-2-hydroxy-1-methyl-2-phenyl-ethyl)-4H-cyclopentisoxazole

<3R^*,4α,5α>-3a,5,6,6a-tetrahydro-3-(syn-2-hydroxy-1-methyl-2-phenyl-ethyl)-4H-cyclopentisoxazole

<3S^*,4α,5α>-3a,5,6,6a-tetrahydro-3-(1-methyl-2-phenylethyl)-4H-cyclopentisoxazole

<3R^*,4α,5α>-3a,5,6,6a-tetrahydro-3-(1-methyl-2-phenylethyl)-4H-cyclopentisoxazole

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