8a-hydroxytetrahydro-5H-oxazolo[3,2-a]pyridin-3(2H)-one

Base Information

Chemical Name:8a-hydroxytetrahydro-5H-oxazolo[3,2-a]pyridin-3(2H)-one
CAS No.:875-07-0
Molecular Formula:C₇H₁₁NO₃
Molecular Weight:157.169
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8a-hydroxytetrahydro-5H-oxazolo[3,2-a]pyridin-3(2H)-one

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Technology Process of 8a-hydroxytetrahydro-5H-oxazolo[3,2-a]pyridin-3(2H)-one

There total 4 articles about 8a-hydroxytetrahydro-5H-oxazolo[3,2-a]pyridin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 840-11-9
1-(2-(benzyloxy)acetyl)piperidin-2-one

: 875-07-0
8a-hydroxytetrahydro-5H-oxazolo[3,2-a]pyridin-3(2H)-one

: 89775-79-1
1-(2-hydroxyacetyl)piperidine-2-one

Guidance literature:: 1-(2-(benzyloxy)acetyl)piperidin-2-one; With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

With triethylamine; In chloroform; at 20 ℃; for 16h; Overall yield = 90 %; Overall yield = 109 mg; Inert atmosphere;
DOI:10.1002/chem.201803064

Reference yield:

: 675-20-7
piperidin-2-one

: 875-07-0
8a-hydroxytetrahydro-5H-oxazolo[3,2-a]pyridin-3(2H)-one

: 89775-79-1
1-(2-hydroxyacetyl)piperidine-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; pyridine / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

1.2: 16 h / 50 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.2: 16 h / 20 °C / Inert atmosphere

With pyridine; dmap; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; dichloromethane;
DOI:10.1002/chem.201803064

Reference yield:

: 89775-79-1
1-(2-hydroxyacetyl)piperidine-2-one

: 875-07-0
8a-hydroxytetrahydro-5H-oxazolo[3,2-a]pyridin-3(2H)-one

Guidance literature:: With potassium chloride; In phosphate buffer; water-d2; Further Variations:; Solvents; Equilibrium constant;
DOI:10.1021/jo702003q