C₃₅H₄₃N₇O₅

Base Information

• Chemical Name: C₃₅H₄₃N₇O₅
• CAS No.: 1610758-19-4
• Molecular Formula: C₃₅H₄₃N₇O₅
• Molecular Weight: 641.77
• Mol file: 1610758-19-4.mol

Synonyms:

Chemical Property of C₃₅H₄₃N₇O₅

Chemical Property:

• Melting Point: >124°C (dec.)
• Density: 1.23±0.1 g/cm3(Predicted)

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

O-DesethylO-IsopropylDabigatranEtexilate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: O-Desethyl O-Isopropyl Dabigatran Etexilate is an impurity of Dabigatran Etexilate Mesylate (D100150). Dabigatran Etexilate Mesylate is a nonpeptide, direct thrombin inhibitor and an Antithrombotic agent.

Technology Process of C₃₅H₄₃N₇O₅

There total 3 articles about C₃₅H₄₃N₇O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.6%

n-hexyl chloroformate (6092-54-2) + C28H31N7O3*C7H8O3S (1610758-18-3) → C35H43N7O5 (1610758-19-4)

Guidance literature:

With potassium carbonate; at 20 ℃; for 2h;

DOI:10.1021/op500084q

Reference yield:

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester (211915-84-3) → C35H43N7O5 (1610758-19-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / water; ethanol / 2 h / 20 °C

2.1: hydrogenchloride / 8 h / 20 °C

2.2: 5 h / 0 - 20 °C

3.1: potassium carbonate / 2 h / 20 °C

With hydrogenchloride; potassium carbonate; sodium hydroxide; In ethanol; water;

DOI:10.1021/op500084q

Reference yield:

3-(2-(((4-cyanophenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propionic acid (212322-77-5) → C35H43N7O5 (1610758-19-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / 8 h / 20 °C

1.2: 5 h / 0 - 20 °C

2.1: potassium carbonate / 2 h / 20 °C

With hydrogenchloride; potassium carbonate;

DOI:10.1021/op500084q

upstream raw materials:

n-hexyl chloroformate

C₂₈H₃₁N₇O₃*C₇H₈O₃S

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

3-(2-(((4-cyanophenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propionic acid

Refernces