N-[(1S,2S)-3-cyclopropylcarbamoyl-1-(3,5-difluorophenoxymethyl)-2-hydroxy-propyl]-5-((methanesulfonyl)(methyl)amino)-N'-((R)-1-phenyl-ethyl)-isophthalic acid diamide

Base Information

Chemical Name:N-[(1S,2S)-3-cyclopropylcarbamoyl-1-(3,5-difluorophenoxymethyl)-2-hydroxy-propyl]-5-((methanesulfonyl)(methyl)amino)-N'-((R)-1-phenyl-ethyl)-isophthalic acid diamide
CAS No.:1092973-34-6
Molecular Formula:C₃₂H₃₆F₂N₄O₇S
Molecular Weight:658.723
Hs Code.:

N-[(1S,2S)-3-cyclopropylcarbamoyl-1-(3,5-difluorophenoxymethyl)-2-hydroxy-propyl]-5-((methanesulfonyl)(methyl)amino)-N'-((R)-1-phenyl-ethyl)-isophthalic acid diamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(1S,2S)-3-cyclopropylcarbamoyl-1-(3,5-difluorophenoxymethyl)-2-hydroxy-propyl]-5-((methanesulfonyl)(methyl)amino)-N'-((R)-1-phenyl-ethyl)-isophthalic acid diamide

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Technology Process of N-[(1S,2S)-3-cyclopropylcarbamoyl-1-(3,5-difluorophenoxymethyl)-2-hydroxy-propyl]-5-((methanesulfonyl)(methyl)amino)-N'-((R)-1-phenyl-ethyl)-isophthalic acid diamide

There total 1 articles about N-[(1S,2S)-3-cyclopropylcarbamoyl-1-(3,5-difluorophenoxymethyl)-2-hydroxy-propyl]-5-((methanesulfonyl)(methyl)amino)-N'-((R)-1-phenyl-ethyl)-isophthalic acid diamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₄H₁₈F₂N₂O₃

: 695215-92-0
3-[methyl(methylsulfonyl)amino]-5-((1R)-1-phenylethylaminocarbonyl)benzoate acid

: 1092973-34-6
N-[(1S,2S)-3-cyclopropylcarbamoyl-1-(3,5-difluorophenoxymethyl)-2-hydroxy-propyl]-5-((methanesulfonyl)(methyl)amino)-N'-((R)-1-phenyl-ethyl)-isophthalic acid diamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2.5h;
DOI:10.1016/j.bmc.2008.09.041