(S)-2-((S)-1-Benzyloxycarbonylmethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylamino)-6-[2-(tert-butoxycarbonyl-methyl-amino)-ethylamino]-hexanoic acid benzyl ester

Base Information

Chemical Name:(S)-2-((S)-1-Benzyloxycarbonylmethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylamino)-6-[2-(tert-butoxycarbonyl-methyl-amino)-ethylamino]-hexanoic acid benzyl ester
CAS No.:1027168-88-2
Molecular Formula:C₄₀H₅₂N₄O₇
Molecular Weight:700.875
Hs Code.:

(S)-2-((S)-1-Benzyloxycarbonylmethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylamino)-6-[2-(tert-butoxycarbonyl-methyl-amino)-ethylamino]-hexanoic acid benzyl ester

Synonyms:

Suppliers and Price of (S)-2-((S)-1-Benzyloxycarbonylmethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylamino)-6-[2-(tert-butoxycarbonyl-methyl-amino)-ethylamino]-hexanoic acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-((S)-1-Benzyloxycarbonylmethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylamino)-6-[2-(tert-butoxycarbonyl-methyl-amino)-ethylamino]-hexanoic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-((S)-1-Benzyloxycarbonylmethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylamino)-6-[2-(tert-butoxycarbonyl-methyl-amino)-ethylamino]-hexanoic acid benzyl ester

There total 4 articles about (S)-2-((S)-1-Benzyloxycarbonylmethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylamino)-6-[2-(tert-butoxycarbonyl-methyl-amino)-ethylamino]-hexanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: 1027168-88-2
(S)-2-((S)-1-Benzyloxycarbonylmethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylamino)-6-[2-(tert-butoxycarbonyl-methyl-amino)-ethylamino]-hexanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Cs₂CO₃ / dimethylformamide / 48 h / Ambient temperature

2: 90 percent / HCl / ethyl acetate / 16 h

3: NaBH₃CN, molecular sieves / methanol

With hydrogenchloride; molecular sieve; sodium cyanoborohydride; caesium carbonate; In methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00038a011

Reference yield:

: 97878-50-7
(S)-6-tert-Butoxycarbonylamino-2-((S)-1-carboxymethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylamino)-hexanoic acid

: 1027168-88-2
(S)-2-((S)-1-Benzyloxycarbonylmethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylamino)-6-[2-(tert-butoxycarbonyl-methyl-amino)-ethylamino]-hexanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Cs₂CO₃ / dimethylformamide / 48 h / Ambient temperature

2: 90 percent / HCl / ethyl acetate / 16 h

3: NaBH₃CN, molecular sieves / methanol

With hydrogenchloride; molecular sieve; sodium cyanoborohydride; caesium carbonate; In methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00038a011

Reference yield:

: 158387-21-4
6-<<(1,1-dimethylethoxy)carbonyl>amino>-2-<1-<<(benzyloxy)carbonyl>methyl>-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>hexanoic acid benzyl ester

: 1027168-88-2
(S)-2-((S)-1-Benzyloxycarbonylmethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylamino)-6-[2-(tert-butoxycarbonyl-methyl-amino)-ethylamino]-hexanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / HCl / ethyl acetate / 16 h

2: NaBH₃CN, molecular sieves / methanol

With hydrogenchloride; molecular sieve; sodium cyanoborohydride; In methanol; ethyl acetate;
DOI:10.1021/jm00038a011