5'-monomethoxytritylthymidyl(3'-5')-3'-monomethoxytritylthymidyl O-methyl phosphate

Base Information

Chemical Name:5'-monomethoxytritylthymidyl(3'-5')-3'-monomethoxytritylthymidyl O-methyl phosphate
CAS No.:84718-98-9
Molecular Formula:C₆₁H₆₁N₄O₁₄P
Molecular Weight:1105.15
Hs Code.:

Synonyms:5'-monomethoxytritylthymidyl(3'-5')-3'-monomethoxytritylthymidyl O-methyl phosphate

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Chemical Property of 5'-monomethoxytritylthymidyl(3'-5')-3'-monomethoxytritylthymidyl O-methyl phosphate

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Technology Process of 5'-monomethoxytritylthymidyl(3'-5')-3'-monomethoxytritylthymidyl O-methyl phosphate

There total 1 articles about 5'-monomethoxytritylthymidyl(3'-5')-3'-monomethoxytritylthymidyl O-methyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 3279-26-3
methyl dichlorophosphite

: 42926-80-7
5'-O-(4-monomethoxytrityl)-2'-deoxythymidine

: 13084-61-2
3'-O-(4-methoxytriphenylmethyl)thymidine

: 84718-98-9
5'-monomethoxytritylthymidyl(3'-5')-3'-monomethoxytritylthymidyl O-methyl phosphate

Guidance literature:: With 2,3,5-trimethyl-pyridine; water; iodine; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)88727-4

Reference yield: 91.0%

: 84718-98-9
5'-monomethoxytritylthymidyl(3'-5')-3'-monomethoxytritylthymidyl O-methyl phosphate

: 75-64-9
tert-butylamine

: 5'-monomethoxytritylthymidyl(3'-5')-3'-monomethoxytritylthymidyl phosphate

Guidance literature:: DOI:10.1016/S0040-4039(00)88727-4

Reference yield:

: 84718-98-9
5'-monomethoxytritylthymidyl(3'-5')-3'-monomethoxytritylthymidyl O-methyl phosphate

: 5'-monomethoxytritylthymidil(3'-5')-3'-monomethoxytritylthymidyl O,O-phosphorothioate

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent

2: 1.)Dowex(Py⁺) 2.)Ph₃P-CCl₄

3: 85 percent / NaH/CS₂ / dimethylformamide

With carbon disulfide; triphenylphosphine-carbon tetrachloride; Dowex(Py⁺); sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)88727-4