((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-methyl-butyrylamino]-propionylamino}-4-methyl-pentanoylamino)-acetic acid benzyl ester; compound with trifluoro-acetic acid

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Chemical Name:((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-methyl-butyrylamino]-propionylamino}-4-methyl-pentanoylamino)-acetic acid benzyl ester; compound with trifluoro-acetic acid
CAS No.:82882-81-3
Molecular Formula:C₂HF₃O₂*C₃₂H₄₅N₅O₆
Molecular Weight:709.763
Hs Code.:

((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-methyl-butyrylamino]-propionylamino}-4-methyl-pentanoylamino)-acetic acid benzyl ester; compound with trifluoro-acetic acid

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Chemical Property of ((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-methyl-butyrylamino]-propionylamino}-4-methyl-pentanoylamino)-acetic acid benzyl ester; compound with trifluoro-acetic acid

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Technology Process of ((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-methyl-butyrylamino]-propionylamino}-4-methyl-pentanoylamino)-acetic acid benzyl ester; compound with trifluoro-acetic acid

There total 8 articles about ((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-methyl-butyrylamino]-propionylamino}-4-methyl-pentanoylamino)-acetic acid benzyl ester; compound with trifluoro-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4070-48-8
L-Valine methyl ester

: 82882-81-3
((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-methyl-butyrylamino]-propionylamino}-4-methyl-pentanoylamino)-acetic acid benzyl ester; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / DCC / dimethylformamide; tetrahydrofuran

2: 83 percent / 80percent hydrazine hydrate / methanol / Ambient temperature

3: isoamylnitrite / dimethylformamide; triethylamine

4: Et₃N / dimethylformamide / 48 h / 4 °C

5: anisole / 1 h / 0 °C

With hydrazine hydrate; methoxybenzene; triethylamine; dicyclohexyl-carbodiimide; isopentyl nitrite; In tetrahydrofuran; methanol; triethylamine; N,N-dimethyl-formamide;
DOI:10.1248/cpb.30.1697

Reference yield:

: 23234-86-8
N-(4-methoxybenzyloxycarbonyl)-L-phenylalanine

: 82882-81-3
((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-methyl-butyrylamino]-propionylamino}-4-methyl-pentanoylamino)-acetic acid benzyl ester; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / DCC / dimethylformamide; tetrahydrofuran

2: 83 percent / 80percent hydrazine hydrate / methanol / Ambient temperature

3: isoamylnitrite / dimethylformamide; triethylamine

4: Et₃N / dimethylformamide / 48 h / 4 °C

5: anisole / 1 h / 0 °C

With hydrazine hydrate; methoxybenzene; triethylamine; dicyclohexyl-carbodiimide; isopentyl nitrite; In tetrahydrofuran; methanol; triethylamine; N,N-dimethyl-formamide;
DOI:10.1248/cpb.30.1697

Reference yield:

: 82882-75-5
Z(OMe)-Phe-Val-OMe

: 82882-81-3
((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-methyl-butyrylamino]-propionylamino}-4-methyl-pentanoylamino)-acetic acid benzyl ester; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / 80percent hydrazine hydrate / methanol / Ambient temperature

2: isoamylnitrite / dimethylformamide; triethylamine

3: Et₃N / dimethylformamide / 48 h / 4 °C

4: anisole / 1 h / 0 °C

With hydrazine hydrate; methoxybenzene; triethylamine; isopentyl nitrite; In methanol; triethylamine; N,N-dimethyl-formamide;
DOI:10.1248/cpb.30.1697