C₅₈H₅₈ClN₈O₁₄P

Base Information

Chemical Name:C₅₈H₅₈ClN₈O₁₄P
CAS No.:83327-02-0
Molecular Formula:C₅₈H₅₈ClN₈O₁₄P
Molecular Weight:1157.57
Hs Code.:

C<sub>58</sub>H<sub>58</sub>ClN<sub>8</sub>O<sub>14</sub>P

Synonyms:

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Chemical Property of C₅₈H₅₈ClN₈O₁₄P

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Technology Process of C₅₈H₅₈ClN₈O₁₄P

There total 14 articles about C₅₈H₅₈ClN₈O₁₄P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 81196-20-5
2-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl phosphate

: 83327-02-0
C₅₈H₅₈ClN₈O₁₄P

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) 2,4,6-triisopropylbenzenesulfonyl chloride / 1.) N-methylimidazole / 2.) pyridine, 30 min

2: hydrazine hydrate / pyridine; acetic acid / 0.75 h

With 2,4,6-triisopropylphenylsulfonyl chloride; hydrazine hydrate; 1-methyl-1H-imidazole; In pyridine; acetic acid;
DOI:10.1016/0040-4020(84)85098-X

Reference yield:

: 961-07-9
2'-Deoxyguanosine

: 83327-02-0
C₅₈H₅₈ClN₈O₁₄P

Guidance literature:: Multi-step reaction with 10 steps

1: 92 percent / pyridine / 1 h

2: Et₃N / 4-dimethylaminopyridine / CH₂Cl₂ / 2 h / Ambient temperature

3: 1.) Me₃N; 2.) NH₃ / CH₂Cl₂ / 1.) 0 deg C; 2.) 5 h, reflux

4: pyridine / 1 h

5: 1.4 g / 1 N NaOH / pyridine; H₂O / 0.17 h / 0 °C

6: pyridine / 3 h

7: Et₃N, 4-dimethylaminopyridine / diethyl ether; pyridine / Ambient temperature

8: 1.6 g / tetra-n-butylammonium flouride / tetrahydrofuran / 0.5 h

9: 2.) 2,4,6-triisopropylbenzenesulfonyl chloride / 1.) N-methylimidazole / 2.) pyridine, 30 min

10: hydrazine hydrate / pyridine; acetic acid / 0.75 h

With dmap; sodium hydroxide; 2,4,6-triisopropylphenylsulfonyl chloride; tetrabutyl ammonium fluoride; ammonia; hydrazine hydrate; triethylamine; trimethylamine; 1-methyl-1H-imidazole; dmap; In tetrahydrofuran; pyridine; diethyl ether; dichloromethane; water; acetic acid;
DOI:10.1016/0040-4020(84)85098-X

Reference yield:

: 82921-43-5
2-N-3',5'-O-triisobutyryl-6-O-(2,4,6-triisopropylbenzenesulfonyl)-2'-deoxyguanosine

: 83327-02-0
C₅₈H₅₈ClN₈O₁₄P

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) Me₃N; 2.) NH₃ / CH₂Cl₂ / 1.) 0 deg C; 2.) 5 h, reflux

2: pyridine / 1 h

3: 1.4 g / 1 N NaOH / pyridine; H₂O / 0.17 h / 0 °C

4: pyridine / 3 h

5: Et₃N, 4-dimethylaminopyridine / diethyl ether; pyridine / Ambient temperature

6: 1.6 g / tetra-n-butylammonium flouride / tetrahydrofuran / 0.5 h

7: 2.) 2,4,6-triisopropylbenzenesulfonyl chloride / 1.) N-methylimidazole / 2.) pyridine, 30 min

8: hydrazine hydrate / pyridine; acetic acid / 0.75 h

With dmap; sodium hydroxide; 2,4,6-triisopropylphenylsulfonyl chloride; tetrabutyl ammonium fluoride; ammonia; hydrazine hydrate; triethylamine; trimethylamine; 1-methyl-1H-imidazole; In tetrahydrofuran; pyridine; diethyl ether; dichloromethane; water; acetic acid;
DOI:10.1016/0040-4020(84)85098-X