1-[2-(tert-butyl-dimethyl-silanyloxy)-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-4-[1-(7-iodo-furo[3,2-c]pyridin-2-yl)-1-methyl-ethyl]-piperazine-2-carboxylic acid tert-butylamide

Base Information

Chemical Name:1-[2-(tert-butyl-dimethyl-silanyloxy)-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-4-[1-(7-iodo-furo[3,2-c]pyridin-2-yl)-1-methyl-ethyl]-piperazine-2-carboxylic acid tert-butylamide
CAS No.:501676-27-3
Molecular Formula:C₄₆H₆₄IN₅O₅Si
Molecular Weight:922.035
Hs Code.:

1-[2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-4-[1-(7-iodo-furo[3,2-<i>c</i>]pyridin-2-yl)-1-methyl-ethyl]-piperazine-2-carboxylic acid <i>tert</i>-butylamide

Synonyms:

Suppliers and Price of 1-[2-(tert-butyl-dimethyl-silanyloxy)-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-4-[1-(7-iodo-furo[3,2-c]pyridin-2-yl)-1-methyl-ethyl]-piperazine-2-carboxylic acid tert-butylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[2-(tert-butyl-dimethyl-silanyloxy)-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-4-[1-(7-iodo-furo[3,2-c]pyridin-2-yl)-1-methyl-ethyl]-piperazine-2-carboxylic acid tert-butylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[2-(tert-butyl-dimethyl-silanyloxy)-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-4-[1-(7-iodo-furo[3,2-c]pyridin-2-yl)-1-methyl-ethyl]-piperazine-2-carboxylic acid tert-butylamide

There total 9 articles about 1-[2-(tert-butyl-dimethyl-silanyloxy)-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-4-[1-(7-iodo-furo[3,2-c]pyridin-2-yl)-1-methyl-ethyl]-piperazine-2-carboxylic acid tert-butylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7153-08-4
4-hydroxy-3,5-diiodopyridine

: 501676-27-3
1-[2-(tert-butyl-dimethyl-silanyloxy)-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-4-[1-(7-iodo-furo[3,2-c]pyridin-2-yl)-1-methyl-ethyl]-piperazine-2-carboxylic acid tert-butylamide

Guidance literature:: Multi-step reaction with 5 steps

1: CuI; N-ethylpiperidine / dimethylformamide

2: LiOH / tetrahydrofuran

3: DIEA / tetrahydrofuran

4: H₂O / tetrahydrofuran

5: HBTU; HOBt; DIEA / dimethylformamide

With 1-ethyl-piperidine; lithium hydroxide; copper(l) iodide; water; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Castro-Stevens reaction;
DOI:10.1016/S0960-894X(02)00424-9

Reference yield:

: 1111-97-3
3-chloro-3-methylbut-1-yne

: 501676-27-3
1-[2-(tert-butyl-dimethyl-silanyloxy)-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-4-[1-(7-iodo-furo[3,2-c]pyridin-2-yl)-1-methyl-ethyl]-piperazine-2-carboxylic acid tert-butylamide

Guidance literature:: Multi-step reaction with 6 steps

1: Cu; CuCl; Et₃N / tetrahydrofuran

2: CuI; N-ethylpiperidine / dimethylformamide

3: LiOH / tetrahydrofuran

4: DIEA / tetrahydrofuran

5: H₂O / tetrahydrofuran

6: HBTU; HOBt; DIEA / dimethylformamide

With 1-ethyl-piperidine; lithium hydroxide; copper(l) iodide; water; copper; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; copper(l) chloride; In tetrahydrofuran; N,N-dimethyl-formamide; 2: Castro-Stevens reaction;
DOI:10.1016/S0960-894X(02)00424-9

Reference yield:

: 150323-36-7
dihydro-5(S)-<<4-<(1,1-dimethylethoxy)carbonyl>-2(S)-(N-tert-butylcarbamoyl)piperazinyl>methyl>-3(R)-(phenylmethyl)-3(2H)-furanone

: 501676-27-3
1-[2-(tert-butyl-dimethyl-silanyloxy)-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-4-[1-(7-iodo-furo[3,2-c]pyridin-2-yl)-1-methyl-ethyl]-piperazine-2-carboxylic acid tert-butylamide

Guidance literature:: Multi-step reaction with 7 steps

1: TFA / CH₂Cl₂ / 1 h

2: Cu; CuCl; Et₃N / tetrahydrofuran

3: CuI; N-ethylpiperidine / dimethylformamide

4: LiOH / tetrahydrofuran

5: DIEA / tetrahydrofuran

6: H₂O / tetrahydrofuran

7: HBTU; HOBt; DIEA / dimethylformamide

With 1-ethyl-piperidine; lithium hydroxide; copper(l) iodide; water; copper; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; copper(l) chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3: Castro-Stevens reaction;
DOI:10.1016/S0960-894X(02)00424-9