N-{(Z)-2-bromo-3-[1-(2,4,6-trimethylphenylsulfonyl)-1H-indol-3-yl]prop-2-enyl}-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-{(Z)-2-bromo-3-[1-(2,4,6-trimethylphenylsulfonyl)-1H-indol-3-yl]prop-2-enyl}-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide
• CAS No.: 1342341-00-7
• Molecular Formula: C₄₀H₄₇BrN₂O₄S₂
• Molecular Weight: 763.86
• Mol file: 1342341-00-7.mol

Synonyms:

Chemical Property of N-{(Z)-2-bromo-3-[1-(2,4,6-trimethylphenylsulfonyl)-1H-indol-3-yl]prop-2-enyl}-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{(Z)-2-bromo-3-[1-(2,4,6-trimethylphenylsulfonyl)-1H-indol-3-yl]prop-2-enyl}-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide

There total 12 articles about N-{(Z)-2-bromo-3-[1-(2,4,6-trimethylphenylsulfonyl)-1H-indol-3-yl]prop-2-enyl}-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-mesitylenesulphonyl chloride (773-64-8) + N-[(Z)-2-bromo-3-(1H-indol-3-yl)prop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide (1342341-47-2) → N-{(Z)-2-bromo-3-[1-(2,4,6-trimethylphenylsulfonyl)-1H-indol-3-yl]prop-2-enyl}-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide (1342341-00-7)

Guidance literature:

N-[(Z)-2-bromo-3-(1H-indol-3-yl)prop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide; With sodium hydride; In tetrahydrofuran; mineral oil; Cooling;

2-mesitylenesulphonyl chloride; In tetrahydrofuran; mineral oil; for 3h; Cooling;

DOI:10.1055/s-0030-1260098

Reference yield:

(Z)-2-bromo-3-[N-(4-methylphenylsulfonyl)-1H-indol-3-yl]prop-2-en-1-ol → N-{(Z)-2-bromo-3-[1-(2,4,6-trimethylphenylsulfonyl)-1H-indol-3-yl]prop-2-enyl}-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide (1342341-00-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 40 °C

2.1: sodium hydride / tetrahydrofuran; ethanol / 9 h / 0 - 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / Cooling

3.2: 3 h / Cooling

With di-isopropyl azodicarboxylate; sodium hydride; triphenylphosphine; In tetrahydrofuran; ethanol; mineral oil;

DOI:10.1055/s-0030-1260098

Reference yield:

N-{(Z)-2-bromo-3-[N-(4-methylphenylsulfonyl)-1H-indol-3-yl]prop-2-enyl}-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide → N-{(Z)-2-bromo-3-[1-(2,4,6-trimethylphenylsulfonyl)-1H-indol-3-yl]prop-2-enyl}-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide (1342341-00-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; ethanol / 9 h / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / Cooling

2.2: 3 h / Cooling

With sodium hydride; In tetrahydrofuran; ethanol; mineral oil;

DOI:10.1055/s-0030-1260098

upstream raw materials:

2-mesitylenesulphonyl chloride

N-[(Z)-2-bromo-3-(1H-indol-3-yl)prop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide

Indole-3-carboxaldehyde

C₁₂H₁₀BrNO₂

Downstream raw materials:

(3R)-4-butyl-3-cyclohexyl-2-(4-methylphenylsulfonyl)-5-(2,4,6-trimethylphenylsulfonyl)-1,2,3,5-tetrahydropyrrolo[3,4-b]carbazole