N-[(Z)-2-bromo-3-(1H-indol-3-yl)prop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-[(Z)-2-bromo-3-(1H-indol-3-yl)prop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide
CAS No.:1342341-47-2
Molecular Formula:C₃₁H₃₇BrN₂O₂S
Molecular Weight:581.617
Hs Code.:

Synonyms:N-[(Z)-2-bromo-3-(1H-indol-3-yl)prop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide

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Chemical Property of N-[(Z)-2-bromo-3-(1H-indol-3-yl)prop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide

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Technology Process of N-[(Z)-2-bromo-3-(1H-indol-3-yl)prop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide

There total 11 articles about N-[(Z)-2-bromo-3-(1H-indol-3-yl)prop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: N-{(Z)-2-bromo-3-[N-(4-methylphenylsulfonyl)-1H-indol-3-yl]prop-2-enyl}-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide

: 1342341-47-2
N-[(Z)-2-bromo-3-(1H-indol-3-yl)prop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide

Guidance literature:: With sodium hydride; In tetrahydrofuran; ethanol; at 0 - 20 ℃; for 9h;
DOI:10.1055/s-0030-1260098

Reference yield: 67.0%

: 1342341-01-8
methyl 3-[(Z)-2-bromo-3-{N-[(1S)-1-cyclohexylhept-2-ynyl]-N-(4-methylphenylsulfonyl)amino}prop-1-enyl]-1H-indole-1-carboxylate

: 1342341-47-2
N-[(Z)-2-bromo-3-(1H-indol-3-yl)prop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide

Guidance literature:: With palladium diacetate; caesium carbonate; In ethanol; for 1h; Reflux;
DOI:10.1055/s-0030-1260098

Reference yield:

: (Z)-2-bromo-3-[N-(4-methylphenylsulfonyl)-1H-indol-3-yl]prop-2-en-1-ol

: 1342341-47-2
N-[(Z)-2-bromo-3-(1H-indol-3-yl)prop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 40 °C

2: sodium hydride / tetrahydrofuran; ethanol / 9 h / 0 - 20 °C

With di-isopropyl azodicarboxylate; sodium hydride; triphenylphosphine; In tetrahydrofuran; ethanol;
DOI:10.1055/s-0030-1260098