C₂₈H₄₂N₈O₁₀P^(1-)*Na⁽¹⁺⁾

Base Information

• Chemical Name: C₂₈H₄₂N₈O₁₀P^(1-)*Na⁽¹⁺⁾
• CAS No.: 1379798-42-1
• Molecular Formula: C₂₈H₄₂N₈O₁₀P*Na
• Molecular Weight: 704.653
• Mol file: 1379798-42-1.mol

Synonyms:

Chemical Property of C₂₈H₄₂N₈O₁₀P^(1-)*Na⁽¹⁺⁾

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₄₂N₈O₁₀P^(1-)*Na⁽¹⁺⁾

There total 5 articles about C₂₈H₄₂N₈O₁₀P^(1-)*Na⁽¹⁺⁾ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

Ac-Ala-Lys-Ala-NH2 (927677-20-1) + C16H17N3O8P(1-)*Na(1+) (1379798-20-5) → C28H42N8O10P(1-)*Na(1+) (1379798-42-1) + C30H44N8O11P(1-)*Na(1+) (1379798-38-5)

Guidance literature:

Ac-Ala-Lys-Ala-NH₂; C₁₆H₁₇N₃O₈P^(1-)*Na⁽¹⁺⁾; In methanol; for 1h; Inert atmosphere;

With sodium cyanoborohydride; In methanol; at 20 ℃; for 24h; Inert atmosphere;

In water; Inert atmosphere;

DOI:10.1002/chem.201103270

Reference yield: 51.0%

Ac-Ala-Lys-Ala-NH2 (927677-20-1) + C16H17N3O8P(1-)*Na(1+) (1379798-20-5) → C16H19N3O8P(1-)*Na(1+) (1379798-28-3) + C28H42N8O10P(1-)*Na(1+) (1379798-42-1) + C30H44N8O11P(1-)*Na(1+) (1379798-38-5)

Guidance literature:

Ac-Ala-Lys-Ala-NH₂; C₁₆H₁₇N₃O₈P^(1-)*Na⁽¹⁺⁾; In glycerol; for 1h; Inert atmosphere;

With sodium cyanoborohydride; In glycerol; at 20 ℃; for 24h; Inert atmosphere;

In water; Inert atmosphere;

DOI:10.1002/chem.201103270

Reference yield:

5-Iodo-2'-deoxycytidine (611-53-0) → C28H42N8O10P(1-)*Na(1+) (1379798-42-1) + C30H44N8O11P(1-)*Na(1+) (1379798-38-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trimethyl phosphite; trichlorophosphate / 6 h / 0 - 80 °C / Inert atmosphere

1.2: Dowex 50WX₈ in Na⁺ cycle / Inert atmosphere

2.1: trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; caesium carbonate / water; acetonitrile / 2 h / 90 °C / Inert atmosphere

2.2: Dowex 50WX₈ in Na⁺ cycle / Inert atmosphere

3.1: methanol / 1 h / Inert atmosphere

3.2: 24 h / 20 °C / Inert atmosphere

3.3: Dowex 50WX₈ in Na⁺ cycle / Inert atmosphere

With trimethyl phosphite; trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; caesium carbonate; trichlorophosphate; In methanol; water; acetonitrile; 2.1: Suzuki coupling;

DOI:10.1002/chem.201103270

upstream raw materials:

Ac-Ala-Lys-Ala-NH₂

C₁₆H₁₇N₃O₈P^(1-)*Na⁽¹⁺⁾

5-iodo-2'-deoxycytidine monophosphate

5-Iodo-2'-deoxycytidine