Technology Process of (R)-5-methyl-8-(N4-methylpiperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-ylamine benzoate
There total 10 articles about (R)-5-methyl-8-(N4-methylpiperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-ylamine benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hydroxide / toluene
2: palladium on activated charcoal; hydrogen / water; acetic acid
3: toluene
With
palladium on activated charcoal; hydrogen; sodium hydroxide;
In
water; acetic acid; toluene;
DOI:10.1021/jo300277y
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hydroxide / toluene
2: palladium on activated charcoal; hydrogen / water; acetic acid
3: toluene
With
palladium on activated charcoal; hydrogen; sodium hydroxide;
In
water; acetic acid; toluene;
DOI:10.1021/jo300277y
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: bromine; potassium carbonate / water / 10 - 15 °C / Inert atmosphere
1.2: 6 h / 0 - 60 °C / Inert atmosphere
2.1: thionyl chloride; N,N-dimethyl-formamide / 1,2-dichloro-ethane / 4.5 h / 82 °C
3.1: aluminum (III) chloride / water; 1,2-dichloro-ethane / -4 - 2 °C
4.1: toluene-4-sulfonic acid / toluene / 30 °C / Inert atmosphere
5.1: methanol; sodium tetrahydroborate / isopropyl alcohol / 10 h / -3 - 10 °C
6.1: hydrogenchloride / ethanol / 3 h / 60 °C / Large scale
7.1: sodium hydroxide / toluene / 25 - 60 °C
7.2: 4 h / 40 - 100 °C
8.1: acetic acid; 5%-palladium/activated carbon; hydrogen / water / 5 h / 95 °C
9.1: isopropyl alcohol; toluene / 45 °C
With
hydrogenchloride; methanol; aluminum (III) chloride; sodium tetrahydroborate; thionyl chloride; 5%-palladium/activated carbon; hydrogen; bromine; potassium carbonate; toluene-4-sulfonic acid; acetic acid; N,N-dimethyl-formamide; sodium hydroxide;
In
ethanol; water; 1,2-dichloro-ethane; isopropyl alcohol; toluene;
DOI:10.1021/op8000146
