Technology Process of ((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine hydrochloride
There total 7 articles about ((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
ethanol;
at 60 ℃;
for 3h;
Large scale;
DOI:10.1021/op8000146
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: bromine; potassium carbonate / water / 10 - 15 °C / Inert atmosphere
1.2: 6 h / 0 - 60 °C / Inert atmosphere
2.1: thionyl chloride; N,N-dimethyl-formamide / 1,2-dichloro-ethane / 4.5 h / 82 °C
3.1: aluminum (III) chloride / water; 1,2-dichloro-ethane / -4 - 2 °C
4.1: toluene-4-sulfonic acid / toluene / 30 °C / Inert atmosphere
5.1: methanol; sodium tetrahydroborate / isopropyl alcohol / 10 h / -3 - 10 °C
6.1: hydrogenchloride / ethanol / 3 h / 60 °C / Large scale
With
hydrogenchloride; methanol; aluminum (III) chloride; sodium tetrahydroborate; thionyl chloride; bromine; potassium carbonate; toluene-4-sulfonic acid; N,N-dimethyl-formamide;
In
ethanol; water; 1,2-dichloro-ethane; isopropyl alcohol; toluene;
DOI:10.1021/op8000146
- Guidance literature:
-
With
hydrogenchloride;
In
ethyl acetate;
optical yield given as %de;
DOI:10.1021/jo300277y
