((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine hydrochloride

Base Information

Chemical Name:((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine hydrochloride
CAS No.:1394290-38-0
Molecular Formula:C₁₉H₂₂BrN*ClH
Molecular Weight:380.755
Hs Code.:

Synonyms:((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine hydrochloride

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Chemical Property of ((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine hydrochloride

Chemical Property:

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Technology Process of ((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine hydrochloride

There total 7 articles about ((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 951155-03-6
((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine

: 1394290-38-0
((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; at 60 ℃; for 3h; Large scale;
DOI:10.1021/op8000146

Reference yield:

: 621-36-3
m-methylphenylacetic acid

: 1394290-38-0
((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: bromine; potassium carbonate / water / 10 - 15 °C / Inert atmosphere

1.2: 6 h / 0 - 60 °C / Inert atmosphere

2.1: thionyl chloride; N,N-dimethyl-formamide / 1,2-dichloro-ethane / 4.5 h / 82 °C

3.1: aluminum (III) chloride / water; 1,2-dichloro-ethane / -4 - 2 °C

4.1: toluene-4-sulfonic acid / toluene / 30 °C / Inert atmosphere

5.1: methanol; sodium tetrahydroborate / isopropyl alcohol / 10 h / -3 - 10 °C

6.1: hydrogenchloride / ethanol / 3 h / 60 °C / Large scale

With hydrogenchloride; methanol; aluminum (III) chloride; sodium tetrahydroborate; thionyl chloride; bromine; potassium carbonate; toluene-4-sulfonic acid; N,N-dimethyl-formamide; In ethanol; water; 1,2-dichloro-ethane; isopropyl alcohol; toluene;
DOI:10.1021/op8000146