3-hydroxy-N'-[1-(2-naphthyl)ethylidene]-2-naphthohydrazide

Base Information

• Chemical Name: 3-hydroxy-N'-[1-(2-naphthyl)ethylidene]-2-naphthohydrazide
• CAS No.: 1393656-31-9
• Molecular Formula: C₂₃H₁₈N₂O₂
• Molecular Weight: 354.408
• Mol file: 1393656-31-9.mol

Synonyms:

Chemical Property of 3-hydroxy-N'-[1-(2-naphthyl)ethylidene]-2-naphthohydrazide

Chemical Property:

Purity/Quality:

3-hydroxy-N'-[1-(2-naphthyl)ethylidene]-2-naphthohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-hydroxy-N'-[1-(2-naphthyl)ethylidene]-2-naphthohydrazide

There total 4 articles about 3-hydroxy-N'-[1-(2-naphthyl)ethylidene]-2-naphthohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

3-hydroxy-2-naphthohydrazide (5341-58-2) + methyl 2-naphthyl ketone (93-08-3) → (E)-3-hydroxy-N'-(1-(naphthalene-2-yl)ethylidene)-2-naphthohydrazide (1393656-31-9)

Guidance literature:

In ethanol; at 120 ℃; for 3h;

DOI:10.1021/ci300299n

Reference yield:

3-Hydroxy-2-naphthoic acid (92-70-6) → (E)-3-hydroxy-N'-(1-(naphthalene-2-yl)ethylidene)-2-naphthohydrazide (1393656-31-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 8 h / Reflux

2: hydrazine hydrate / ethanol / 8 h / Reflux

3: ethanol / 20 h / Reflux; Inert atmosphere

With sulfuric acid; hydrazine hydrate; In ethanol;

DOI:10.1016/j.ejmech.2013.10.063

Reference yield:

3-hydroxy-2-naphthoic acid methyl ester (883-99-8) → (E)-3-hydroxy-N'-(1-(naphthalene-2-yl)ethylidene)-2-naphthohydrazide (1393656-31-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 8 h / Reflux

2: ethanol / 20 h / Reflux; Inert atmosphere

With hydrazine hydrate; In ethanol;

DOI:10.1016/j.ejmech.2013.10.063

upstream raw materials:

3-hydroxy-2-naphthohydrazide

methyl 2-naphthyl ketone

3-Hydroxy-2-naphthoic acid

3-hydroxy-2-naphthoic acid methyl ester

Refernces

• 1、 Blanco, Fernando,Caboni, Laura,Fayne, Darren,Lloyd, David G.,Egan, Billy,Meegan, Mary J.,O'Brien, John,McCabe, Thomas,Elguero, Jose. "Study of E/Z isomerization in a series of novel non-ligand binding pocket androgen receptor antagonists". . p. 2387 - 2397,11. Retrieved 2020/08/24.