Technology Process of (1S,3S,4R)-4-<(triphenylmethoxy)methyl>cyclopentane-1,3-diyl sulfate
There total 8 articles about (1S,3S,4R)-4-<(triphenylmethoxy)methyl>cyclopentane-1,3-diyl sulfate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 80 percent / 2,6-lutidine / CH2Cl2 / 0 deg C, 10 min; without cooling, 30 min
2: 95 percent / H2 / 3)3> / tetrahydrofuran / 5 h / 80 °C / 60004.8 Torr / Au-coated autoclave
3: 98 percent / NaBH4 / tetrahydrofuran; H2O / 0.17 h / 0 °C
4: 88 percent / 4-(dimethylamino)pyridine, Et3N / CH2Cl2 / 18 h / Ambient temperature
5: Bu4NF*3H2O / tetrahydrofuran / 5 h / Ambient temperature
7: SOCl2, Et3N / CH2Cl2 / 0.32 h / 0 °C
8: NaIO4, RuCl3*H2O / acetonitrile; CCl4; H2O / 1 h / 0 °C
With
2,6-dimethylpyridine; dmap; ruthenium trichloride; sodium tetrahydroborate; sodium periodate; thionyl chloride; tetrabutyl ammonium fluoride; hydrogen; triethylamine;
Wilkinson's catalyst;
In
tetrahydrofuran; tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1002/hlca.19940770608
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 95 percent / H2 / 3)3> / tetrahydrofuran / 5 h / 80 °C / 60004.8 Torr / Au-coated autoclave
2: 98 percent / NaBH4 / tetrahydrofuran; H2O / 0.17 h / 0 °C
3: 88 percent / 4-(dimethylamino)pyridine, Et3N / CH2Cl2 / 18 h / Ambient temperature
4: Bu4NF*3H2O / tetrahydrofuran / 5 h / Ambient temperature
6: SOCl2, Et3N / CH2Cl2 / 0.32 h / 0 °C
7: NaIO4, RuCl3*H2O / acetonitrile; CCl4; H2O / 1 h / 0 °C
With
dmap; ruthenium trichloride; sodium tetrahydroborate; sodium periodate; thionyl chloride; tetrabutyl ammonium fluoride; hydrogen; triethylamine;
Wilkinson's catalyst;
In
tetrahydrofuran; tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1002/hlca.19940770608
- Guidance literature:
-
With
ruthenium trichloride; sodium periodate;
In
tetrachloromethane; water; acetonitrile;
at 0 ℃;
for 1h;
Yield given;
DOI:10.1002/hlca.19940770608
