tert-butyl [(1R,2R)-2-[methyl[2-[1-[((R)-1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methyl]-1H-1,2,3-triazol-5-yl]ethyl]amino]cyclohexyl]carbamate

Base Information

Chemical Name:tert-butyl [(1R,2R)-2-[methyl[2-[1-[((R)-1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methyl]-1H-1,2,3-triazol-5-yl]ethyl]amino]cyclohexyl]carbamate
CAS No.:1256601-47-4
Molecular Formula:C₂₃H₃₇F₃N₆O₃
Molecular Weight:502.58
Hs Code.:

tert-butyl [(1R,2R)-2-[methyl[2-[1-[((R)-1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methyl]-1H-1,2,3-triazol-5-yl]ethyl]amino]cyclohexyl]carbamate

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Chemical Property of tert-butyl [(1R,2R)-2-[methyl[2-[1-[((R)-1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methyl]-1H-1,2,3-triazol-5-yl]ethyl]amino]cyclohexyl]carbamate

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Technology Process of tert-butyl [(1R,2R)-2-[methyl[2-[1-[((R)-1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methyl]-1H-1,2,3-triazol-5-yl]ethyl]amino]cyclohexyl]carbamate

There total 5 articles about tert-butyl [(1R,2R)-2-[methyl[2-[1-[((R)-1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methyl]-1H-1,2,3-triazol-5-yl]ethyl]amino]cyclohexyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1229407-43-5
(R)-1-(2-(azidomethyl)-1-pyrrolidinyl)-2,2,2-trifluoroethanone

: 1256601-44-1
tert-butyl (1R,2R)-2-(3-butynyl(methyl)amino)cyclohexylcarbamate

: 1256601-47-4
tert-butyl [(1R,2R)-2-[methyl[2-[1-[((R)-1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methyl]-1H-1,2,3-triazol-5-yl]ethyl]amino]cyclohexyl]carbamate

Guidance literature:: With chloro(pentamethylcyclopentadienyl)ruthenium(II) tetramer; In tetrahydrofuran; for 8h; regioselective reaction; Inert atmosphere; Reflux;
DOI:10.3390/molecules15118327

Reference yield:

: C₁₄H₁₆F₃NO₄S

: 1256601-47-4
tert-butyl [(1R,2R)-2-[methyl[2-[1-[((R)-1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methyl]-1H-1,2,3-triazol-5-yl]ethyl]amino]cyclohexyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide; sodium iodide / 1,4-dioxane; dimethyl sulfoxide / 80 °C / Inert atmosphere

2: chloro(pentamethylcyclopentadienyl)ruthenium(II) tetramer / tetrahydrofuran / 8 h / Inert atmosphere; Reflux

With sodium azide; chloro(pentamethylcyclopentadienyl)ruthenium(II) tetramer; sodium iodide; In tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide; 2: Huisgen reaction;
DOI:10.3390/molecules15118327

Reference yield:

: 1256601-43-0
tert-butyl (1R,2R)-2-(3-butynylamino)cyclohexylcarbamate

: 1256601-47-4
tert-butyl [(1R,2R)-2-[methyl[2-[1-[((R)-1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methyl]-1H-1,2,3-triazol-5-yl]ethyl]amino]cyclohexyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; acetonitrile / 1 h / 20 °C / Inert atmosphere

1.2: 4 h / 20 °C / Inert atmosphere

2.1: chloro(pentamethylcyclopentadienyl)ruthenium(II) tetramer / tetrahydrofuran / 8 h / Inert atmosphere; Reflux

With chloro(pentamethylcyclopentadienyl)ruthenium(II) tetramer; In tetrahydrofuran; water; acetonitrile; 2.1: Huisgen reaction;
DOI:10.3390/molecules15118327