1,3-Benzenedicarboxamide, N,N'-diphenyl-

Base Information

• Chemical Name: 1,3-Benzenedicarboxamide, N,N'-diphenyl-
• CAS No.: 13111-32-5
• Molecular Formula: C20H16N2O2
• Molecular Weight: 316.359
• Mol file: 13111-32-5.mol

Synonyms:N,N'-Diphenyl-isophthalamide;isophthalanilide;diphenylene isophthalamide;N,N'-diphenyl-1,3-benzenedicarboxamide;1,3-diphenylterephthaloyldiamide;Isophthalic acid dianilide;

Chemical Property of 1,3-Benzenedicarboxamide, N,N'-diphenyl-

Chemical Property:

• PSA: 65.18000
• LogP: 4.95920

Purity/Quality:

99% ^*data from raw suppliers

1,3-Benzenedicarboxamide,N1,N3-diphenyl 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-Benzenedicarboxamide, N,N'-diphenyl-

There total 8 articles about 1,3-Benzenedicarboxamide, N,N'-diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

aniline (62-53-3) + benzene-1,3-dicarbonyl dichloride (99-63-8) → isophthalic acid dianilide (13111-32-5)

Guidance literature:

With triethylamine; In 1-methyl-pyrrolidin-2-one; for 0.5h; Inert atmosphere; Cooling with ice;

DOI:10.1039/d0gc03470c

Reference yield:

aniline (62-53-3) → isophthalic acid dianilide (13111-32-5)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene; phosphorus (III)-chloride

2: toluene

With toluene; phosphorus trichloride;

DOI:10.1021/ja01208a001

Reference yield:

isophthalic acid (121-91-5) → isophthalic acid dianilide (13111-32-5)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 4 h / 80 °C

2: pyridine / 2 h / 20 °C / Inert atmosphere

With pyridine; thionyl chloride;

DOI:10.1021/acs.jmedchem.6b00719

upstream raw materials:

isophthalic acid

2,4-bis(anilino)-1,3-diphenyl-1,3,2,4-diazadiphosphetidine

phenyl isocyanate

aniline

Downstream raw materials:

N,N'-diphenylisophthalimidoyl chloride

N,N'-dimethyl-N,N'-diphenyl-1,3-benzenedicarboxamide

Refernces

• 1、 Lukin, Oleg,Kubota, Takateru,Okamoto, Yoshio,Schelhase, Frauke,Yoneva, Albena,Mueller, Walter M.,Mueller, Ute,Voegtle, Fritz. "Knotaxanes - Rotaxanes with knots as stoppers". . p. 4542 - 4545. Retrieved 2003.
• 2、 Winters, Jonas,Bolia, Raheed,Dehaen, Wim,Binnemans, Koen. "Synthesis of polyaramids in γ-valerolactone-based organic electrolyte solutions". supporting information. p. 1228 - 1239. Retrieved 2021/02/26.
• 3、 Wicht, Kathryn J.,Combrinck, Jill M.,Smith, Peter J.,Hunter, Roger,Egan, Timothy J.. "Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum". . p. 6512 - 6530. Retrieved 2016/07/23.