Toluene-4-sulfonic acid (3R,5S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-5-hydroxy-10,13-dimethyl-6-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Base Information

• Chemical Name: Toluene-4-sulfonic acid (3R,5S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-5-hydroxy-10,13-dimethyl-6-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester
• CAS No.: 20352-33-4
• Molecular Formula: C₃₄H₅₂O₅S
• Molecular Weight: 572.85
• Mol file: 20352-33-4.mol

Synonyms:

Chemical Property of Toluene-4-sulfonic acid (3R,5S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-5-hydroxy-10,13-dimethyl-6-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Toluene-4-sulfonic acid (3R,5S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-5-hydroxy-10,13-dimethyl-6-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

There total 10 articles about Toluene-4-sulfonic acid (3R,5S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-5-hydroxy-10,13-dimethyl-6-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3β,5-dihydroxy-5α-cholestan-6-one (2953-37-9,6580-08-1,16526-63-9,97100-50-0,115792-36-4,13027-33-3) + p-toluenesulfonyl chloride (98-59-9) → 5α-hydroxy-3β-p-toluenesulfonyloxycholestan-6-one (6770-44-1,20352-33-4,2762-57-4)

Guidance literature:

DOI:10.1021/jo50005a014 DOI:10.1021/jo01094a032

Reference yield:

Toluene-4-sulfonic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-20-oxa-cyclopropa[5,6]cyclopenta[a]phenanthren-3-yl ester → 5α-hydroxy-3β-p-toluenesulfonyloxycholestan-6-one (6770-44-1,20352-33-4,2762-57-4)

Guidance literature:

With chromium(VI) oxide; In butanone; at 20 ℃;

DOI:10.1021/jm010867n

Reference yield:

cholesteryl p-toluenesulfonate (1182-65-6,3381-56-4) → 5α-hydroxy-3β-p-toluenesulfonyloxycholestan-6-one (6770-44-1,20352-33-4,2762-57-4)

Guidance literature:

Multistep reaction; (i) monoperoxyphthalic acid, (ii) aq. CrO₃;

upstream raw materials:

3β,5-dihydroxy-5α-cholestan-6-one

p-toluenesulfonyl chloride

cholesteryl p-toluenesulfonate

cholesterol

Downstream raw materials:

5α-cholestan-6-one

Toluene-4-sulfonic acid (3R,5S,6R,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-5,6-dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester