Trichloro-acetic acid 1-benzyloxymethyl-4-(2-chloro-ethyl)-2-methyl-5-(2,2,2-trichloro-acetylamino)-1H-indol-7-yl ester

Base Information

• Chemical Name: Trichloro-acetic acid 1-benzyloxymethyl-4-(2-chloro-ethyl)-2-methyl-5-(2,2,2-trichloro-acetylamino)-1H-indol-7-yl ester
• CAS No.: 118667-75-7
• Molecular Formula: C₂₃H₁₉Cl₇N₂O₄
• Molecular Weight: 635.586
• Mol file: 118667-75-7.mol

Synonyms:

Chemical Property of Trichloro-acetic acid 1-benzyloxymethyl-4-(2-chloro-ethyl)-2-methyl-5-(2,2,2-trichloro-acetylamino)-1H-indol-7-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Trichloro-acetic acid 1-benzyloxymethyl-4-(2-chloro-ethyl)-2-methyl-5-(2,2,2-trichloro-acetylamino)-1H-indol-7-yl ester

There total 1 articles about Trichloro-acetic acid 1-benzyloxymethyl-4-(2-chloro-ethyl)-2-methyl-5-(2,2,2-trichloro-acetylamino)-1H-indol-7-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C19H20N2O2 (118667-72-4) + trifluoroacetyl chloride (76-02-8) → Trichloro-acetic acid 1-benzyloxymethyl-4-(2-chloro-ethyl)-2-methyl-5-(2,2,2-trichloro-acetylamino)-1H-indol-7-yl ester (118667-75-7)

Guidance literature:

With dmap; triethylamine; In chloroform; at 0 ℃;

DOI:10.1016/S0040-4039(00)86700-3

Reference yield:

Trichloro-acetic acid 1-benzyloxymethyl-4-(2-chloro-ethyl)-2-methyl-5-(2,2,2-trichloro-acetylamino)-1H-indol-7-yl ester (118667-75-7) → 1-(6-Benzyloxymethyl-5-hydroxy-7-methyl-1,6-dihydro-2H-pyrrolo[3,2-e]indol-3-yl)-2,2,2-trichloro-ethanone

Guidance literature:

With water; potassium carbonate; In acetone;

DOI:10.1016/S0040-4039(00)86700-3

Reference yield:

Trichloro-acetic acid 1-benzyloxymethyl-4-(2-chloro-ethyl)-2-methyl-5-(2,2,2-trichloro-acetylamino)-1H-indol-7-yl ester (118667-75-7) → 1-(6-Benzyloxymethyl-5-methoxy-7-methyl-1,6-dihydro-2H-pyrrolo[3,2-e]indol-3-yl)-2,2,2-trichloro-ethanone (118667-76-8)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃, H₂O / acetone

With water; potassium carbonate; In acetone;

DOI:10.1016/S0040-4039(00)86700-3

upstream raw materials:

C₁₉H₂₀N₂O₂

trifluoroacetyl chloride

Downstream raw materials:

1-(6-Benzyloxymethyl-5-methoxy-7-methyl-1,6-dihydro-2H-pyrrolo[3,2-e]indol-3-yl)-2,2,2-trichloro-ethanone