C₁₆H₁₃Cl₃N₂O₃

Base Information

• Chemical Name: C₁₆H₁₃Cl₃N₂O₃
• CAS No.: 1350292-83-9
• Molecular Formula: C₁₆H₁₃Cl₃N₂O₃
• Molecular Weight: 387.65
• Mol file: 1350292-83-9.mol

Synonyms:

Chemical Property of C₁₆H₁₃Cl₃N₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₁₃Cl₃N₂O₃

There total 4 articles about C₁₆H₁₃Cl₃N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H12Cl2N2O2 (1306233-16-8) + chloroacetyl chloride (79-04-9) → C16H13Cl3N2O3 (1350292-83-9)

Guidance literature:

With triethylamine; In 1,2-dichloro-ethane; at 20 ℃; for 3h;

DOI:10.1016/j.bmcl.2011.09.046

Reference yield:

C14H10Cl2N2O4 (1350292-82-8) → C16H13Cl3N2O3 (1350292-83-9)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / tetrahydrofuran / 4 h / 20 °C

2: triethylamine / 1,2-dichloro-ethane / 3 h / 20 °C

With palladium on activated charcoal; hydrogen; triethylamine; In tetrahydrofuran; 1,2-dichloro-ethane;

DOI:10.1016/j.bmcl.2011.09.046

Reference yield:

3-nitro-4-fluorobenzoic acid (453-71-4) → C16H13Cl3N2O3 (1350292-83-9)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride / 24 h / 20 °C

2: trans-bis(triphenylphosphine)palladium dichloride; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 12 h / Inert atmosphere; Reflux

3: palladium on activated charcoal; hydrogen / tetrahydrofuran / 4 h / 20 °C

4: triethylamine / 1,2-dichloro-ethane / 3 h / 20 °C

With thionyl chloride; trans-bis(triphenylphosphine)palladium dichloride; palladium on activated charcoal; hydrogen; potassium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,2-dichloro-ethane; toluene;

DOI:10.1016/j.bmcl.2011.09.046

upstream raw materials:

C₁₄H₁₀Cl₂N₂O₄

C₁₄H₁₂Cl₂N₂O₂

chloroacetyl chloride

3-nitro-4-fluorobenzoic acid

Downstream raw materials:

C₁₆H₁₂Cl₂N₂O₃

C₂₈H₂₉Cl₂N₅O₃