Phosphoric acid (3aS,4S,5R,6aR)-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(tetrahydro-pyran-2-yloxy)-1,3a,4,5,6,6a-hexahydro-pentalen-2-yl ester diphenyl ester

Base Information

Chemical Name:Phosphoric acid (3aS,4S,5R,6aR)-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(tetrahydro-pyran-2-yloxy)-1,3a,4,5,6,6a-hexahydro-pentalen-2-yl ester diphenyl ester
CAS No.:114647-36-8
Molecular Formula:C₄₂H₄₉O₇PSi
Molecular Weight:724.906
Hs Code.:

Phosphoric acid (3aS,4S,5R,6aR)-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(tetrahydro-pyran-2-yloxy)-1,3a,4,5,6,6a-hexahydro-pentalen-2-yl ester diphenyl ester

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Chemical Property of Phosphoric acid (3aS,4S,5R,6aR)-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(tetrahydro-pyran-2-yloxy)-1,3a,4,5,6,6a-hexahydro-pentalen-2-yl ester diphenyl ester

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Technology Process of Phosphoric acid (3aS,4S,5R,6aR)-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(tetrahydro-pyran-2-yloxy)-1,3a,4,5,6,6a-hexahydro-pentalen-2-yl ester diphenyl ester

There total 6 articles about Phosphoric acid (3aS,4S,5R,6aR)-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(tetrahydro-pyran-2-yloxy)-1,3a,4,5,6,6a-hexahydro-pentalen-2-yl ester diphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 114647-36-8
Phosphoric acid (3aS,4S,5R,6aR)-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(tetrahydro-pyran-2-yloxy)-1,3a,4,5,6,6a-hexahydro-pentalen-2-yl ester diphenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 960 g / p-TsOH / CH₂Cl₂ / 0.5 h

2: 1.) lithium dicyclohexylamide / 1.) THF, hexane, 10 min; 2.) room temp., 20 min

With lithium dicyclohexylamide; toluene-4-sulfonic acid; In dichloromethane;
DOI:10.1248/cpb.35.4000

Reference yield:

: 70871-22-6
(1S,2R,3R,5R)-2-hydroxymethyl-3-(tetrahydropyran-2-yl)oxy-7,7-ethylenedioxybicyclo<3.3.0>octane

: 114647-36-8
Phosphoric acid (3aS,4S,5R,6aR)-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(tetrahydro-pyran-2-yloxy)-1,3a,4,5,6,6a-hexahydro-pentalen-2-yl ester diphenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 17.8 g / imidazole / dimethylformamide / 1 h / Ambient temperature

2: 0.982 g / AcOH / tetrahydrofuran; H₂O / 7 h / 45 - 50 °C

3: 960 g / p-TsOH / CH₂Cl₂ / 0.5 h

4: 1.) lithium dicyclohexylamide / 1.) THF, hexane, 10 min; 2.) room temp., 20 min

With 1H-imidazole; lithium dicyclohexylamide; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.35.4000

Reference yield:

: 114647-28-8
(1R,5S,6S,7R)-3-oxo-6-(tert-butyldiphenylsilyloxymethyl)-7-hydroxybicyclo<3.3.0>octane

: 114647-36-8
Phosphoric acid (3aS,4S,5R,6aR)-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(tetrahydro-pyran-2-yloxy)-1,3a,4,5,6,6a-hexahydro-pentalen-2-yl ester diphenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 960 g / p-TsOH / CH₂Cl₂ / 0.5 h

2: 1.) lithium dicyclohexylamide / 1.) THF, hexane, 10 min; 2.) room temp., 20 min

With lithium dicyclohexylamide; toluene-4-sulfonic acid; In dichloromethane;
DOI:10.1248/cpb.35.4000