1-P-TOLYL-1-TOSYLMETHYL ISOCYANIDE

Base Information

• Chemical Name: 1-P-TOLYL-1-TOSYLMETHYL ISOCYANIDE
• CAS No.: 1330529-37-7
• Molecular Formula: C₁₆H₁₅NO₂S
• Molecular Weight: 285.367
• Mol file: 1330529-37-7.mol

Synonyms:

Chemical Property of 1-P-TOLYL-1-TOSYLMETHYL ISOCYANIDE

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-((Isocyano(p-tolyl)methyl)sulfonyl)-4-methylbenzene 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-P-TOLYL-1-TOSYLMETHYL ISOCYANIDE

There total 6 articles about 1-P-TOLYL-1-TOSYLMETHYL ISOCYANIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

N-[4-methylphenyl(toluene-4-sulfonyl)methyl]formamide → 1-((isocyano(p-tolyl)methyl)sulfonyl)-4-methylbenzene (1330529-37-7)

Guidance literature:

With 2,6-dimethylpyridine; trichlorophosphate; at -10 - 20 ℃; for 16h;

Reference yield:

p-toluene sulfinic acid (536-57-2) + 4-methyl-benzaldehyde (104-87-0) → 1-((isocyano(p-tolyl)methyl)sulfonyl)-4-methylbenzene (1330529-37-7)

Guidance literature:

Multi-step reaction with 2 steps

1: camphor-10-sulfonic acid / 18 h / 60 °C

2: trichlorophosphate; 2,6-dimethylpyridine / 16 h / -10 - 20 °C

With 2,6-dimethylpyridine; camphor-10-sulfonic acid; trichlorophosphate;

Reference yield:

sodium tosylate (657-84-1) → 1-((isocyano(p-tolyl)methyl)sulfonyl)-4-methylbenzene (1330529-37-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride / water; diethyl ether / 0.5 h

2.1: chloro-trimethyl-silane / toluene; acetonitrile / 5 h / 50 °C

3.1: trichlorophosphate / tetrahydrofuran / 0.08 h / 25 °C

3.2: 0.75 h / 0 - 10 °C

With hydrogenchloride; chloro-trimethyl-silane; trichlorophosphate; In tetrahydrofuran; diethyl ether; water; toluene; acetonitrile;

upstream raw materials:

sodium tosylate

toluene-4-sulfonic acid

p-toluene sulfinic acid

4-methyl-benzaldehyde