Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE

Base Information

• Chemical Name: Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE
• CAS No.: 114014-15-2
• Molecular Formula: C₃₁H₃₄N₄O₅
• Molecular Weight: 542.635
• Mol file: 114014-15-2.mol

Synonyms:

Chemical Property of Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE

Chemical Property:

• Storage Temp.: -15°C

Purity/Quality:

99%+, ^*data from raw suppliers

CathepsinLinhibitorIII >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE

There total 4 articles about Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Cbz-L-Phe (1161-13-3) → Z-FY(t-Bu)-dmk (114014-15-2)

Guidance literature:

Multi-step reaction with 3 steps

2: N-methylmorpholine / 0.25 h / 0 °C

3: diethyl ether / 0 - 20 °C

With 4-methyl-morpholine; In diethyl ether; 2: Acylation / 3: Substitution;

DOI:10.1016/S0960-894X(00)00340-1

Reference yield:

Fmoc-Tyr(tBu)-OH (71989-38-3,118488-18-9,204384-67-8) → Z-FY(t-Bu)-dmk (114014-15-2)

Guidance literature:

Multi-step reaction with 3 steps

2: N-methylmorpholine / 0.25 h / 0 °C

3: diethyl ether / 0 - 20 °C

With 4-methyl-morpholine; In diethyl ether; 2: Acylation / 3: Substitution;

DOI:10.1016/S0960-894X(00)00340-1

Reference yield:

Z-Phe-Tyr(OBut)-OH (69538-46-1) → Z-FY(t-Bu)-dmk (114014-15-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylmorpholine / 0.25 h / 0 °C

2: diethyl ether / 0 - 20 °C

With 4-methyl-morpholine; In diethyl ether; 1: Acylation / 2: Substitution;

DOI:10.1016/S0960-894X(00)00340-1

upstream raw materials:

diazomethane

N-Cbz-L-Phe

Fmoc-Tyr(tBu)-OH

Z-Phe-Tyr(OBut)-OH

Refernces