Oxazole, 2,2'-(1,2-phenylene)bis[4,5-dihydro-4-(1-methylethyl)-, (4S,4'S)-

Base Information

Chemical Name:Oxazole, 2,2'-(1,2-phenylene)bis[4,5-dihydro-4-(1-methylethyl)-, (4S,4'S)-
CAS No.:131380-80-8
Molecular Formula:C18H24N2O2
Molecular Weight:300.401
Hs Code.:

Synonyms:

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Chemical Property of Oxazole, 2,2'-(1,2-phenylene)bis[4,5-dihydro-4-(1-methylethyl)-, (4S,4'S)-

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Technology Process of Oxazole, 2,2'-(1,2-phenylene)bis[4,5-dihydro-4-(1-methylethyl)-, (4S,4'S)-

There total 2 articles about Oxazole, 2,2'-(1,2-phenylene)bis[4,5-dihydro-4-(1-methylethyl)-, (4S,4'S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 2026-48-4,473-75-6
(S)-valinol

: 91-15-6
phthalonitrile

: 131380-80-8
1,2-bis[(4S)-(4-isopropyl-Δ²-1,3-oxazolin-2-yl)]benzene

Guidance literature:: In neat (no solvent); at 150 ℃; for 1h; Microwave irradiation;
DOI:10.1016/j.tetasy.2014.08.010

Reference yield: 53.0%

: 2026-48-4,473-75-6
(S)-valinol

: 91-15-6
phthalonitrile

: (S)-2-(4-isopropyl-4,5-dihydrooxazol-2-yl)benzonitrile

: 131380-80-8
1,2-bis[(4S)-(4-isopropyl-Δ²-1,3-oxazolin-2-yl)]benzene

Guidance literature:: With zinc(II) chloride; In chlorobenzene; for 15h; Reflux;
DOI:10.1002/chem.201505009

Reference yield: 98.0%

: ammonium hexafluorophosphate

: di-μ-chlorido-bis(η3-1,3-diphenylallyl)dipalladium(II)

: 131380-80-8
1,2-bis[(4S)-(4-isopropyl-Δ²-1,3-oxazolin-2-yl)]benzene

: (η(3)-1,3-diphenylallyl)[1,2-bis[(4S)-4-isopropyl-Δ(2)-1,3-oxazolin-2-yl]benzene-N,N]palladium(II) hexafluorophosphate

Guidance literature:: In ethanol; dichloromethane; Pd complex and ligand (molar ratio 0.12:0.25) dissolved in a mixt. of equal amts. of abs. EtOH, CH2Cl2, CHCl3 and MeOH under N2; stirred at roomtemp. for 30 min; NH4PF6 added; stirred at room temp. for 3 d; evapd., dissolved in CH2Cl2, extd. with H2O until neutral pH; org. phasedried over Na2SO4, evapd., Et2O added; resulting white solid dried in v acuo; elem. anal.; single crystal X-ray diffraction;