C₁₆H₁₅ClFNO₂

Base Information

Chemical Name:C₁₆H₁₅ClFNO₂
CAS No.:1403226-60-7
Molecular Formula:C₁₆H₁₅ClFNO₂
Molecular Weight:307.752
Hs Code.:

C<sub>16</sub>H<sub>15</sub>ClFNO<sub>2</sub>

Synonyms:

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Chemical Property of C₁₆H₁₅ClFNO₂

Chemical Property:

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Technology Process of C₁₆H₁₅ClFNO₂

There total 6 articles about C₁₆H₁₅ClFNO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2941-78-8
2-Amino-5-methylbenzoic acid

: 1403226-60-7
C₁₆H₁₅ClFNO₂

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; copper(II) acetate monohydrate / 1,4-dioxane / 25 °C

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0 °C

2.2: 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4.1: pyridine; thionyl chloride / tetrahydrofuran / 0.25 h / 0 - 5 °C / Inert atmosphere

5.1: dimethyl sulfoxide / 1.5 h / Inert atmosphere

6.1: water; sodium hydroxide / ethanol / 24 h / Reflux

With pyridine; lithium aluminium tetrahydride; thionyl chloride; water; copper(II) acetate monohydrate; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil; 1.1: |Chan-Lam Coupling;
DOI:10.1002/cmdc.201200272

Reference yield:

: 313545-32-3
(2-chloro-6-fluorophenyl)boronic acid

: 1403226-60-7
C₁₆H₁₅ClFNO₂

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; copper(II) acetate monohydrate / 1,4-dioxane / 25 °C

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0 °C

2.2: 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4.1: pyridine; thionyl chloride / tetrahydrofuran / 0.25 h / 0 - 5 °C / Inert atmosphere

5.1: dimethyl sulfoxide / 1.5 h / Inert atmosphere

6.1: water; sodium hydroxide / ethanol / 24 h / Reflux

With pyridine; lithium aluminium tetrahydride; thionyl chloride; water; copper(II) acetate monohydrate; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil; 1.1: |Chan-Lam Coupling;
DOI:10.1002/cmdc.201200272

Reference yield:

: 619296-47-8
2-[(2-chloro-6-fluorophenyl)amino]-5-methyl-benzoic acid

: 1403226-60-7
C₁₆H₁₅ClFNO₂

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0 °C

1.2: 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.1: pyridine; thionyl chloride / tetrahydrofuran / 0.25 h / 0 - 5 °C / Inert atmosphere

4.1: dimethyl sulfoxide / 1.5 h / Inert atmosphere

5.1: water; sodium hydroxide / ethanol / 24 h / Reflux

With pyridine; lithium aluminium tetrahydride; thionyl chloride; water; sodium hydride; sodium hydroxide; In tetrahydrofuran; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/cmdc.201200272