C₁₆H₁₉NO

Base Information

• Chemical Name: C₁₆H₁₉NO
• CAS No.: 1432505-63-9
• Molecular Formula: C₁₆H₁₉NO
• Molecular Weight: 241.333
• Mol file: 1432505-63-9.mol

Synonyms:

Chemical Property of C₁₆H₁₉NO

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₁₉NO

There total 3 articles about C₁₆H₁₉NO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H19NO3 (1432505-59-3) → C16H19NO (1432505-63-9) + C16H19NO

Guidance literature:

With (S)-2-(2-(bis(4-trifluoromethyl-phenyl)-phosphino))-5-(4-trifluoromethyl-phenyl)-4-tert-butyl-4,5-dihydro-oxazole; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In toluene; at 40 ℃; Overall yield = 94 %; Overall yield = 11.3 mg; enantioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1002/chem.201300030

Reference yield:

2,3-dihydro-1-(phenylmethyl)-4(1H)-pyridinone (35487-98-0) → C16H19NO (1432505-63-9) + C16H19NO

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere; Schlenk technique

1.2: 3 h / -78 - 23 °C / Schlenk technique; Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (S)-2-(2-(bis(4-trifluoromethyl-phenyl)-phosphino))-5-(4-trifluoromethyl-phenyl)-4-tert-butyl-4,5-dihydro-oxazole / toluene / 40 °C / Inert atmosphere; Sealed tube

With (S)-2-(2-(bis(4-trifluoromethyl-phenyl)-phosphino))-5-(4-trifluoromethyl-phenyl)-4-tert-butyl-4,5-dihydro-oxazole; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; toluene;

DOI:10.1002/chem.201300030

Reference yield:

C16H17NO3 (1432505-29-7) → C16H19NO (1432505-63-9) + C16H19NO

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (S)-2-(2-(bis(4-trifluoromethyl-phenyl)-phosphino))-5-(4-trifluoromethyl-phenyl)-4-tert-butyl-4,5-dihydro-oxazole / toluene / 40 °C / Inert atmosphere; Sealed tube

With (S)-2-(2-(bis(4-trifluoromethyl-phenyl)-phosphino))-5-(4-trifluoromethyl-phenyl)-4-tert-butyl-4,5-dihydro-oxazole; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydride; In tetrahydrofuran; toluene;

DOI:10.1002/chem.201300030

upstream raw materials:

2,3-dihydro-1-(phenylmethyl)-4(1H)-pyridinone

C₁₆H₁₇NO₃

C₁₇H₁₉NO₃