3-nitro-4-methyl-N-(3-methylphenyl)benzamide

Base Information

• Chemical Name: 3-nitro-4-methyl-N-(3-methylphenyl)benzamide
• CAS No.: 328258-73-7
• Molecular Formula: C₁₅H₁₄N₂O₃
• Molecular Weight: 270.288
• Mol file: 328258-73-7.mol

Synonyms:

Chemical Property of 3-nitro-4-methyl-N-(3-methylphenyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-nitro-4-methyl-N-(3-methylphenyl)benzamide

There total 2 articles about 3-nitro-4-methyl-N-(3-methylphenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-amino-3-methylbenzene (108-44-1) + 4-methyl-3-nitrobenzoyl chloride (10397-30-5) → C15H14N2O3 (328258-73-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 3h;

DOI:10.1016/j.bmcl.2009.09.123

Reference yield:

4-methyl-3-nitrobenzoic acid (96-98-0) + 1-amino-3-methylbenzene (108-44-1) → C15H14N2O3 (328258-73-7)

Guidance literature:

4-methyl-3-nitrobenzoic acid; With thionyl chloride; at 90 ℃; for 1h;

1-amino-3-methylbenzene; With triethylamine; In dichloromethane; at 0 ℃; for 12h;

DOI:10.1021/acs.jmedchem.8b00753

Reference yield:

C15H14N2O3 (328258-73-7) → 3-amino-4-methyl-N-(m-tolyl)benzamide (953894-46-7)

Guidance literature:

With 1% Pd/C; hydrogen; In ethanol; at 25 ℃; for 4h;

DOI:10.1016/j.bmcl.2009.09.123

upstream raw materials:

1-amino-3-methylbenzene

4-methyl-3-nitrobenzoyl chloride

4-methyl-3-nitrobenzoic acid

Downstream raw materials:

3-amino-4-methyl-N-(m-tolyl)benzamide