(S)-1-tert-butyl 2-((1R,3R)-3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamoyl)cyclopentyl) pyrrolidine-1,2-dicarboxylate

Base Information

Chemical Name:(S)-1-tert-butyl 2-((1R,3R)-3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamoyl)cyclopentyl) pyrrolidine-1,2-dicarboxylate
CAS No.:1443511-42-9
Molecular Formula:C₃₄H₅₀ClN₃O₇
Molecular Weight:648.24
Hs Code.:

(S)-1-tert-butyl 2-((1R,3R)-3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamoyl)cyclopentyl) pyrrolidine-1,2-dicarboxylate

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Chemical Property of (S)-1-tert-butyl 2-((1R,3R)-3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamoyl)cyclopentyl) pyrrolidine-1,2-dicarboxylate

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Technology Process of (S)-1-tert-butyl 2-((1R,3R)-3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamoyl)cyclopentyl) pyrrolidine-1,2-dicarboxylate

There total 12 articles about (S)-1-tert-butyl 2-((1R,3R)-3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamoyl)cyclopentyl) pyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 946593-51-7
(R)-2-amino-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methylbutan-1-one hydrochloric acid salt

: 1443511-25-8
C₁₆H₂₅NO₆

: 1443511-42-9
(S)-1-tert-butyl 2-((1R,3R)-3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamoyl)cyclopentyl) pyrrolidine-1,2-dicarboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2013.04.079

Reference yield:

: 7686-77-3
3-cyclopentene-1-carboxylic acid

: 1443511-42-9
(S)-1-tert-butyl 2-((1R,3R)-3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamoyl)cyclopentyl) pyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

2: benzo[1,3,2]dioxaborole; Wilkinson's catalyst

3: dmap; dicyclohexyl-carbodiimide / dichloromethane

4: Chiralpak ADH / 35 °C / 75007.5 Torr

5: hydrogen; palladium(II) hydroxide / ethyl acetate

6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane

With dmap; Wilkinson's catalyst; hydrogen; palladium(II) hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; benzo[1,3,2]dioxaborole; In dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2013.04.079

Reference yield:

: 130762-09-3
benzyl cyclopent‐3‐ene‐1‐carboxylate

: 1443511-42-9
(S)-1-tert-butyl 2-((1R,3R)-3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamoyl)cyclopentyl) pyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: benzo[1,3,2]dioxaborole; Wilkinson's catalyst

2: dmap; dicyclohexyl-carbodiimide / dichloromethane

3: Chiralpak ADH / 35 °C / 75007.5 Torr

4: hydrogen; palladium(II) hydroxide / ethyl acetate

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane

With dmap; Wilkinson's catalyst; hydrogen; palladium(II) hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; benzo[1,3,2]dioxaborole; In dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2013.04.079