tert-butyl {1-(acetylamino)-3-[(6-{[bis(4-methoxyphenyl)methyl]carbamoyl}-5-[(4,6-dimethylpyridin-2-yl)amino]pyridin-3-yl)amino]propan-2-yl}carbamate

Base Information

Chemical Name:tert-butyl {1-(acetylamino)-3-[(6-{[bis(4-methoxyphenyl)methyl]carbamoyl}-5-[(4,6-dimethylpyridin-2-yl)amino]pyridin-3-yl)amino]propan-2-yl}carbamate
CAS No.:1429913-92-7
Molecular Formula:C₃₈H₄₇N₇O₆
Molecular Weight:697.834
Hs Code.:

tert-butyl {1-(acetylamino)-3-[(6-{[bis(4-methoxyphenyl)methyl]carbamoyl}-5-[(4,6-dimethylpyridin-2-yl)amino]pyridin-3-yl)amino]propan-2-yl}carbamate

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Chemical Property of tert-butyl {1-(acetylamino)-3-[(6-{[bis(4-methoxyphenyl)methyl]carbamoyl}-5-[(4,6-dimethylpyridin-2-yl)amino]pyridin-3-yl)amino]propan-2-yl}carbamate

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Technology Process of tert-butyl {1-(acetylamino)-3-[(6-{[bis(4-methoxyphenyl)methyl]carbamoyl}-5-[(4,6-dimethylpyridin-2-yl)amino]pyridin-3-yl)amino]propan-2-yl}carbamate

There total 12 articles about tert-butyl {1-(acetylamino)-3-[(6-{[bis(4-methoxyphenyl)methyl]carbamoyl}-5-[(4,6-dimethylpyridin-2-yl)amino]pyridin-3-yl)amino]propan-2-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 886373-28-0
5-bromo-3-fluoropyridine-2-carbonitrile

: 1429913-92-7
tert-butyl {1-(acetylamino)-3-[(6-{[bis(4-methoxyphenyl)methyl]carbamoyl}-5-[(4,6-dimethylpyridin-2-yl)amino]pyridin-3-yl)amino]propan-2-yl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 0 - 10 °C

2: dihydrogen peroxide; sodium hydroxide / dimethyl sulfoxide / 2 h / Cooling with ice

3: toluene-4-sulfonic acid / toluene / 2 h / Reflux; Dean-Stark

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; dihydrogen peroxide; caesium carbonate; toluene-4-sulfonic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide; toluene;

Reference yield:

: 1429912-89-9
5-bromo-3-[(4,6-dimethylpyridin-2-yl)amino]pyridine-2-carbonitrile

: 1429913-92-7
tert-butyl {1-(acetylamino)-3-[(6-{[bis(4-methoxyphenyl)methyl]carbamoyl}-5-[(4,6-dimethylpyridin-2-yl)amino]pyridin-3-yl)amino]propan-2-yl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: dihydrogen peroxide; sodium hydroxide / dimethyl sulfoxide / 2 h / Cooling with ice

2: toluene-4-sulfonic acid / toluene / 2 h / Reflux; Dean-Stark

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dihydrogen peroxide; caesium carbonate; toluene-4-sulfonic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide; In 1,4-dioxane; dimethyl sulfoxide; toluene;

Reference yield:

: 61040-22-0
N^β-benzyloxycarbonyl-N^α-Boc-(R)-β-aminoalanine methyl ester

: 1429913-92-7
tert-butyl {1-(acetylamino)-3-[(6-{[bis(4-methoxyphenyl)methyl]carbamoyl}-5-[(4,6-dimethylpyridin-2-yl)amino]pyridin-3-yl)amino]propan-2-yl}carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: lithium borohydride / tetrahydrofuran / 1 h / 0 - 20 °C

2: dichloromethane / 12 h / 0 - 20 °C

3: sodium azide / N,N-dimethyl-formamide / 24 h / 50 °C

4: palladium 10% on activated carbon; hydrogen / methanol / 14 h / 20 °C

5: triethylamine / dichloromethane / 1 h / 0 °C

6: palladium 10% on activated carbon; hydrogen / methanol / 14 h / 20 °C

7: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium borohydride; sodium azide; palladium 10% on activated carbon; hydrogen; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;