Technology Process of 1,2,5-triphenylpentan-3-one
There total 4 articles about 1,2,5-triphenylpentan-3-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-chloro-1,4-diphenyl-1-[(4-tolyl)sulfinyl]butan-2-ol;
With
tert-butylmagnesium chloride;
In
tetrahydrofuran;
at -45 ℃;
Inert atmosphere;
With
isopropylmagnesium chloride;
In
tetrahydrofuran;
at -45 - 20 ℃;
Inert atmosphere;
benzyl bromide;
With
N,N,N,N,N,N-hexamethylphosphoric triamide;
In
tetrahydrofuran;
at 20 ℃;
for 1.5h;
Inert atmosphere;
DOI:10.1055/s-0031-1260251
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere
1.2: 0.17 h / -78 °C / Inert atmosphere
2.1: tert-butylmagnesium chloride / tetrahydrofuran / -45 °C / Inert atmosphere
2.2: -45 - 20 °C / Inert atmosphere
2.3: 1.5 h / 20 °C / Inert atmosphere
With
tert-butylmagnesium chloride; lithium diisopropyl amide;
In
tetrahydrofuran;
DOI:10.1055/s-0031-1260251
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-chloro-succinimide / tetrachloromethane / 15 h / 20 °C
2.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere
2.2: 0.17 h / -78 °C / Inert atmosphere
3.1: tert-butylmagnesium chloride / tetrahydrofuran / -45 °C / Inert atmosphere
3.2: -45 - 20 °C / Inert atmosphere
3.3: 1.5 h / 20 °C / Inert atmosphere
With
N-chloro-succinimide; tert-butylmagnesium chloride; lithium diisopropyl amide;
In
tetrahydrofuran; tetrachloromethane;
DOI:10.1055/s-0031-1260251
![1-chloro-1,4-diphenyl-1-[(4-tolyl)sulfinyl]butan-2-ol](/Databaselist/images/loading.webp)
