Technology Process of 1-(2'-bromo-5'-hydroxybenzylidene)-2-carbethoxy-5,7-dimethoxy-6-hydroxy-1,2,3,4-tetrahydroisoquinoline
There total 6 articles about 1-(2'-bromo-5'-hydroxybenzylidene)-2-carbethoxy-5,7-dimethoxy-6-hydroxy-1,2,3,4-tetrahydroisoquinoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 87 percent / methylamine hydrochloride, anhydrous sodium acetate / 16 h / Ambient temperature
2: 92 percent / lithium aluminium hydride / tetrahydrofuran / 2 h / Heating
3: 90 percent / 0.5 h / 140 - 150 °C
4: POCl3 / CHCl3 / 1.) room temp., 1 h; 2.) reflux, 2.5 h.
5: conc. hydrochloric acid / ethanol / 1.5 h / Heating
6: 10percent aq. Na2CO3 / CHCl3 / 10 h / Ambient temperature
With
hydrogenchloride; lithium aluminium tetrahydride; methylamine hydrochloride; sodium acetate; sodium carbonate; trichlorophosphate;
In
tetrahydrofuran; ethanol; chloroform;
DOI:10.1002/jhet.5570250557
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 90 percent / 0.5 h / 140 - 150 °C
2: POCl3 / CHCl3 / 1.) room temp., 1 h; 2.) reflux, 2.5 h.
3: conc. hydrochloric acid / ethanol / 1.5 h / Heating
4: 10percent aq. Na2CO3 / CHCl3 / 10 h / Ambient temperature
With
hydrogenchloride; sodium carbonate; trichlorophosphate;
In
ethanol; chloroform;
DOI:10.1002/jhet.5570250557
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 88 percent / Na2CO3 / ethanol / 24 h / Heating
2: 87 percent / methylamine hydrochloride, anhydrous sodium acetate / 16 h / Ambient temperature
3: 92 percent / lithium aluminium hydride / tetrahydrofuran / 2 h / Heating
4: 90 percent / 0.5 h / 140 - 150 °C
5: POCl3 / CHCl3 / 1.) room temp., 1 h; 2.) reflux, 2.5 h.
6: conc. hydrochloric acid / ethanol / 1.5 h / Heating
7: 10percent aq. Na2CO3 / CHCl3 / 10 h / Ambient temperature
With
hydrogenchloride; lithium aluminium tetrahydride; methylamine hydrochloride; sodium acetate; sodium carbonate; trichlorophosphate;
In
tetrahydrofuran; ethanol; chloroform;
DOI:10.1002/jhet.5570250557