Technology Process of (R)-2-Benzyloxy-3-(14,14,15,15,16,16,16-heptafluoro-hexadecyloxy)-propionaldehyde
There total 10 articles about (R)-2-Benzyloxy-3-(14,14,15,15,16,16,16-heptafluoro-hexadecyloxy)-propionaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: Fe3(CO)12 / 5.5 h / 80 °C
2: Zn powder / acetic acid; diethyl ether / 1 h / Ambient temperature
3: 5 percent methanolic KOH / 2 h / Ambient temperature
4: 85 percent / triphenylphosphine dibromide / dimethylformamide; acetonitrile
5: 40 percent / 0.1 M Li2CuCl4 / tetrahydrofuran / 5 h / Ambient temperature
6: 80 percent / H2 / 5 percent Pd-C / ethanol; acetic acid / Ambient temperature
7: 87 percent / pyridine / 1 h / Ambient temperature
8: 75 percent / 22 percent KH / benzene; paraffin / 1.) 30 min; 2.) 10 h, RT
9: 77 percent / 2 N HCl / tetrahydrofuran / 2 h / Ambient temperature
10: Pb(OAc)4 / benzene / 1 h
With
lead(IV) acetate; hydrogenchloride; potassium hydroxide; hydrogen; potassium hydride; zinc; dibromotriphenylphosphorane;
palladium on activated charcoal; dilithium tetrachlorocuprate; triiron dodecarbonyl;
In
tetrahydrofuran; pyridine; diethyl ether; ethanol; acetic acid; N,N-dimethyl-formamide; acetonitrile; paraffin; benzene;
DOI:10.1248/cpb.35.647
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 40 percent / 0.1 M Li2CuCl4 / tetrahydrofuran / 5 h / Ambient temperature
2: 80 percent / H2 / 5 percent Pd-C / ethanol; acetic acid / Ambient temperature
3: 87 percent / pyridine / 1 h / Ambient temperature
4: 75 percent / 22 percent KH / benzene; paraffin / 1.) 30 min; 2.) 10 h, RT
5: 77 percent / 2 N HCl / tetrahydrofuran / 2 h / Ambient temperature
6: Pb(OAc)4 / benzene / 1 h
With
lead(IV) acetate; hydrogenchloride; hydrogen; potassium hydride;
palladium on activated charcoal; dilithium tetrachlorocuprate;
In
tetrahydrofuran; pyridine; ethanol; acetic acid; paraffin; benzene;
DOI:10.1248/cpb.35.647
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 85 percent / triphenylphosphine dibromide / dimethylformamide; acetonitrile
2: 40 percent / 0.1 M Li2CuCl4 / tetrahydrofuran / 5 h / Ambient temperature
3: 80 percent / H2 / 5 percent Pd-C / ethanol; acetic acid / Ambient temperature
4: 87 percent / pyridine / 1 h / Ambient temperature
5: 75 percent / 22 percent KH / benzene; paraffin / 1.) 30 min; 2.) 10 h, RT
6: 77 percent / 2 N HCl / tetrahydrofuran / 2 h / Ambient temperature
7: Pb(OAc)4 / benzene / 1 h
With
lead(IV) acetate; hydrogenchloride; hydrogen; potassium hydride; dibromotriphenylphosphorane;
palladium on activated charcoal; dilithium tetrachlorocuprate;
In
tetrahydrofuran; pyridine; ethanol; acetic acid; N,N-dimethyl-formamide; acetonitrile; paraffin; benzene;
DOI:10.1248/cpb.35.647
