N-[4-(3,5-dioxo-hexyl)-phenyl]-3-(2-{2-[2-({[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-methyl-carbamoyl}-methoxy)-ethoxy]-ethoxy}-ethoxy)-propionamide

Base Information

Chemical Name:N-[4-(3,5-dioxo-hexyl)-phenyl]-3-(2-{2-[2-({[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-methyl-carbamoyl}-methoxy)-ethoxy]-ethoxy}-ethoxy)-propionamide
CAS No.:929087-80-9
Molecular Formula:C₄₃H₄₉N₅O₁₂S
Molecular Weight:859.954
Hs Code.:

<i>N</i>-[4-(3,5-dioxo-hexyl)-phenyl]-3-(2-{2-[2-({[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-methyl-carbamoyl}-methoxy)-ethoxy]-ethoxy}-ethoxy)-propionamide

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Chemical Property of N-[4-(3,5-dioxo-hexyl)-phenyl]-3-(2-{2-[2-({[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-methyl-carbamoyl}-methoxy)-ethoxy]-ethoxy}-ethoxy)-propionamide

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Technology Process of N-[4-(3,5-dioxo-hexyl)-phenyl]-3-(2-{2-[2-({[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-methyl-carbamoyl}-methoxy)-ethoxy]-ethoxy}-ethoxy)-propionamide

There total 11 articles about N-[4-(3,5-dioxo-hexyl)-phenyl]-3-(2-{2-[2-({[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-methyl-carbamoyl}-methoxy)-ethoxy]-ethoxy}-ethoxy)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 929087-89-8
3-(2-{2-[2-({[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-methyl-carbamoyl}-methoxy)-ethoxy]-ethoxy}-ethoxy)-N-(4-{2-[2-(2-methyl-[1,3]dioxolan-2-ylmethyl)-[1,3]dioxolan-2-yl]-ethyl}-phenyl)-propionamide

: 929087-80-9
N-[4-(3,5-dioxo-hexyl)-phenyl]-3-(2-{2-[2-({[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-methyl-carbamoyl}-methoxy)-ethoxy]-ethoxy}-ethoxy)-propionamide

Guidance literature:: With toluene-4-sulfonic acid; acetone;
DOI:10.1016/j.bmcl.2006.10.009

Reference yield:

: 192650-25-2
6-(4-nitrophenyl)hexane-2,4-dione

: 929087-80-9
N-[4-(3,5-dioxo-hexyl)-phenyl]-3-(2-{2-[2-({[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-methyl-carbamoyl}-methoxy)-ethoxy]-ethoxy}-ethoxy)-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / pTSA / toluene / Heating

2: 95 percent / H₂ / Pd/C / ethyl acetate

3: 74 percent / EDCI / CH₂Cl₂ / 0 °C

4: 86 percent / pTSA; acetone

With hydrogen; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; acetone; palladium on activated charcoal; In dichloromethane; ethyl acetate; toluene;
DOI:10.1016/j.bmcl.2006.10.009

Reference yield:

: 782475-33-6
C₁₆H₂₁NO₆

: 929087-80-9
N-[4-(3,5-dioxo-hexyl)-phenyl]-3-(2-{2-[2-({[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-methyl-carbamoyl}-methoxy)-ethoxy]-ethoxy}-ethoxy)-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / H₂ / Pd/C / ethyl acetate

2: 74 percent / EDCI / CH₂Cl₂ / 0 °C

3: 86 percent / pTSA; acetone

With hydrogen; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; acetone; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2006.10.009