Methyl α-fluoro-α-methylbenzeneacetate

Base Information

• Chemical Name: Methyl α-fluoro-α-methylbenzeneacetate
• CAS No.: 124658-21-5
• Molecular Formula: C₁₀H₁₁FO₂
• Molecular Weight: 182.195
• Mol file: 124658-21-5.mol

Synonyms:

Chemical Property of Methyl α-fluoro-α-methylbenzeneacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl α-fluoro-α-methylbenzeneacetate

There total 13 articles about Methyl α-fluoro-α-methylbenzeneacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

methyl 2-hydroxy-2-phenylpropanoate (20731-95-7) → Methyl α-fluoro-α-methylbenzeneacetate (124658-21-5,204457-44-3)

Guidance literature:

With 4,4'-diaminostilbene-2,2'-disulfonic acid; In dichloromethane; at 4 ℃; for 3h;

DOI:10.1016/S0022-1139(96)03485-9

Reference yield: 70.0%

→ Methyl α-fluoro-α-methylbenzeneacetate (124658-21-5,204457-44-3)

Guidance literature:

Reference yield: 65.0%

2-phenylpropionic acid methyl ester (31508-44-8) → Methyl α-fluoro-α-methylbenzeneacetate (124658-21-5,204457-44-3)

Guidance literature:

With sodium hexamethyldisilazane; N-Fluoro-o-benzenedisulfonimide; In tetrahydrofuran; 1.) -78 deg C, 10 min; -78 to 0 deg C, 0.5 h, 2.) r.t., 2 h;

DOI:10.1021/jo00120a014

upstream raw materials:

2-phenylpropionic acid methyl ester

N-Fluoro-o-benzenedisulfonimide

2-amino-2-phenyl propanoate de methyle

N-fluoro-N-methyl-p-toluene sulfonamide

Downstream raw materials:

methyl 2-fluoro-3-hydroxy-2-phenylpropanoate

(S)-3-fluoro-3-phenyl-1-<(4-methylphenyl)sulphenyl>-2-butanone

(2S,3R)-3-fluoro-3-phenyl-1-<(R)-(4-methylphenyl)sulphinyl>-2-butanol

(2S,3S)-3-fluoro-3-phenyl-1-<(R)-(4-methylphenyl)sulphinyl>-2-butanol