23,24-Bisnorchol-5-ene-3β,22-diol 3β-Tetrahydropyranyl Ether

Base Information

• Chemical Name: 23,24-Bisnorchol-5-ene-3β,22-diol 3β-Tetrahydropyranyl Ether
• CAS No.: 34026-84-1
• Molecular Formula: C₂₇H₄₄O₃
• Molecular Weight: 416.645
• Mol file: 34026-84-1.mol

Synonyms:

Chemical Property of 23,24-Bisnorchol-5-ene-3β,22-diol 3β-Tetrahydropyranyl Ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 23,24-Bisnorchol-5-ene-3β,22-diol 3β-Tetrahydropyranyl Ether

There total 2 articles about 23,24-Bisnorchol-5-ene-3β,22-diol 3β-Tetrahydropyranyl Ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-[10,13-Dimethyl-3-(tetrahydro-pyran-2-yloxy)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-propan-1-ol (34026-84-1,55123-76-7,88547-67-5)

Guidance literature:

Dihydropyran geschuetzter Alkohol 7c, LiAlH4 - Reduktion;

DOI:10.1021/jm00211a002

Reference yield:

→ 23,24-Bisnorchol-5-en-3,22-diol 3-THP-ether (34026-84-1,55123-76-7,88547-67-5)

Guidance literature:

Verb. 9, 1) alk. Hydrolyse, 2) Dihydropyran, 3) LiAlH4;

Reference yield:

23,24-Bisnorchol-5-ene-3β,22-diol 3β-Tetrahydropyranyl Ether (34026-84-1) → 3β-(Tetrahydropyranyloxy)-23-(tosyloxy)-24-norchol-5-ene (79190-28-6)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / 18 h / 22 °C

2: NaI / acetone / 17 h / Heating

3: n-BuLi/hexane / 1.) THF, -15 deg C, 1 h, 2.) THF, 3 deg C, 15 h

4: Mercuric Oxide, Boron Trifluoride Etherate, p-Toluenesulfonic Acid, LiAlH₄

With lithium aluminium tetrahydride; n-butyllithium; hexane; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; sodium iodide; mercury(II) oxide; In pyridine; acetone;

DOI:10.1021/jo00332a028

Downstream raw materials:

(20S)-(20-Methyl-3β-<(tetrahydropyran-2-yl)oxy>-5-pregnen-21-ol)-p-toluolsulfonat

(25R)-cholest-5-ene-3β,26-diol

3β-(Tetrahydropyranyloxy)-23-(tosyloxy)-24-norchol-5-ene

cholester-23,23,24,24,25,26,26,26,27,27,27-d₁₁-3β-ol