(1aR,3aR,3bS,5aS,8aS,8bR,10R)-6-((R)-1-Benzenesulfinyl-ethyl)-10-methoxy-3a,5a-dimethyl-1,1a,2,3,3a,3b,4,5,5a,8,8a,8b,9,10-tetradecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalene

Base Information

• Chemical Name: (1aR,3aR,3bS,5aS,8aS,8bR,10R)-6-((R)-1-Benzenesulfinyl-ethyl)-10-methoxy-3a,5a-dimethyl-1,1a,2,3,3a,3b,4,5,5a,8,8a,8b,9,10-tetradecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalene
• CAS No.: 93943-33-0
• Molecular Formula: C₂₈H₃₈O₂S
• Molecular Weight: 438.675

Synonyms:

Chemical Property of (1aR,3aR,3bS,5aS,8aS,8bR,10R)-6-((R)-1-Benzenesulfinyl-ethyl)-10-methoxy-3a,5a-dimethyl-1,1a,2,3,3a,3b,4,5,5a,8,8a,8b,9,10-tetradecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1aR,3aR,3bS,5aS,8aS,8bR,10R)-6-((R)-1-Benzenesulfinyl-ethyl)-10-methoxy-3a,5a-dimethyl-1,1a,2,3,3a,3b,4,5,5a,8,8a,8b,9,10-tetradecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalene

There total 4 articles about (1aR,3aR,3bS,5aS,8aS,8bR,10R)-6-((R)-1-Benzenesulfinyl-ethyl)-10-methoxy-3a,5a-dimethyl-1,1a,2,3,3a,3b,4,5,5a,8,8a,8b,9,10-tetradecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1aR,3aR,3bS,5aS,7R,8aS,8bR,10R)-6-Eth-(E)-ylidene-10-methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-7-ol (73668-91-4,73668-92-5,84927-51-5,104171-72-4,104506-40-3) + benzenesulfenyl chloride (931-59-9) → (1aR,3aR,3bS,5aS,8aS,8bR,10R)-6-((S)-1-Benzenesulfinyl-ethyl)-10-methoxy-3a,5a-dimethyl-1,1a,2,3,3a,3b,4,5,5a,8,8a,8b,9,10-tetradecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalene (93943-33-0,93943-34-1,93943-36-3,93943-37-4) + (1aR,3aR,3bS,5aS,8aS,8bR,10R)-6-((R)-1-Benzenesulfinyl-ethyl)-10-methoxy-3a,5a-dimethyl-1,1a,2,3,3a,3b,4,5,5a,8,8a,8b,9,10-tetradecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalene (93943-33-0,93943-34-1,93943-36-3,93943-37-4)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/ja00288a020

Reference yield:

(1aR,3aR,3bS,5aS,7R,8aS,8bR,10R)-6-Eth-(E)-ylidene-10-methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-7-ol (73668-91-4,73668-92-5,84927-51-5,104171-72-4,104506-40-3) + benzenesulfenyl chloride (931-59-9) → (1aR,3aR,3bS,5aS,8aS,8bR,10R)-6-((S)-1-Benzenesulfinyl-ethyl)-10-methoxy-3a,5a-dimethyl-1,1a,2,3,3a,3b,4,5,5a,8,8a,8b,9,10-tetradecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalene (93943-33-0,93943-34-1,93943-36-3,93943-37-4) + (1aR,3aR,3bS,5aS,8aS,8bR,10R)-6-((R)-1-Benzenesulfinyl-ethyl)-10-methoxy-3a,5a-dimethyl-1,1a,2,3,3a,3b,4,5,5a,8,8a,8b,9,10-tetradecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalene (93943-33-0,93943-34-1,93943-36-3,93943-37-4)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/ja00288a020

Reference yield:

(1aR,3aR,3bS,5aS,7S,8aS,8bR,10R)-6-Eth-(E)-ylidene-10-methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-7-ol (73668-91-4,73668-92-5,84927-51-5,104171-72-4,104506-40-3) + benzenesulfenyl chloride (931-59-9) → (1aR,3aR,3bS,5aS,8aS,8bR,10R)-6-((S)-1-Benzenesulfinyl-ethyl)-10-methoxy-3a,5a-dimethyl-1,1a,2,3,3a,3b,4,5,5a,8,8a,8b,9,10-tetradecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalene (93943-33-0,93943-34-1,93943-36-3,93943-37-4) + (1aR,3aR,3bS,5aS,8aS,8bR,10R)-6-((R)-1-Benzenesulfinyl-ethyl)-10-methoxy-3a,5a-dimethyl-1,1a,2,3,3a,3b,4,5,5a,8,8a,8b,9,10-tetradecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalene (93943-33-0,93943-34-1,93943-36-3,93943-37-4)

Guidance literature:

With n-butyllithium; In hexane; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/ja00288a020

upstream raw materials:

(1aR,3aR,3bS,5aS,7R,8aS,8bR,10R)-6-Eth-(E)-ylidene-10-methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-7-ol

benzenesulfenyl chloride

(1aR,3aR,3bS,5aS,7S,8aS,8bR,10R)-6-Eth-(E)-ylidene-10-methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-7-ol

Downstream raw materials:

(20R)-20-(phenylsufonyl)-6β-methoxy-3α,5-cyclo-5α-pregn-16-ene

(20S)-20-(phenylsufonyl)-6β-methoxy-3α,5-cyclo-5-pregn-16-ene

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